Born in Anklam, Western Pomerania, Schweighöfer attended Berlin's renowned acting school Ernst Busch Academy of Dramatic Arts, but dropped out after one year. Nevertheless, the son of actors had already worked with established directors such as Peter Greenaway.
His first role in a feature film was Raus aus der Haut (1997), directed by Andreas Dresen. In the following years, he appeared in projects such as Soloalbum (2003), Off Beat (2004), Eight Miles High (2007) and Rabbit Without Ears. Schweighöfer portrayed Lieutenant-Colonel Franz Herber in Valkyrie, a 2008 film dramatizing the failed 20 July assassination and political coup plot to kill Adolf Hitler. The international release of Valkyrie and the all-star cast (including Tom Cruise, Kenneth Branagh, Terence Stamp and Bill Nighy) not only allowed Schweighöfer to be recognized abroad, it provided an opportunity for him to be cast in other English speaking roles.
In 2010, he made his debut as film director with the romantic comedy What a Man, followed in 2013 by his second movie Break Up Man. In 2017, he directed, produced and played the lead role in You Are Wanted, Amazon Studios' first non-English-language TV series.
In 2021, Schweighöfer appeared in the Netflix film Army of the Dead, directed by Zack Snyder, as Ludwig Dieter. He reprised his role in the prequel film, Army of Thieves, which he also directed.
In 2021/2022, he took on the role of real-life music producer Frank Farian in the biopic Girl You Know It's True about the scandalous pop duo Milli Vanilli, written and directed by Simon Verhoeven, produced by Wiedemann & Berg Film. The film is set to be released theatrically by Leonine in 2023.
Between 2004 and 2012, Schweighöfer dated Ani Schromm, and they got together again in the summer of 2013. They have a daughter born in 2009 and a son born in 2014. Schweighöfer and Schromm later separated, and as of 2019 Schweighöfer has been in a relationship with his Army of Thieves co-star Ruby O. Fee. Schweighöfer currently[when?] lives in Berlin.
- 2000: German Television Prize – Promotional Award for the performance in Verbotenes Verlangen
- 2002: Günter Strack TV Award – Best Young Actor for the performance in Tatort - Gewaltfieber
- 2003: Golden Camera – "Curt Jürgens Memorial Camera" for best newcomer and performances in Die Freunde der Freunde & Soloalbum
- 2003: Adolf Grimme Award – For the performance in Die Freunde der Freunde
- 2003: New Faces Award – Best Actor
- 2004: Bavarian Film Award – Best Young Actor
- 2004: Baden-Baden TV and Film Festival – Special award for the outstanding performances in Baal and Cold Spring
- 2005: Undine Award – Best Young Actor (TV) for the performance in Schiller
- 2006: DIVA-Award – Best Actor for the performances in Kammerflimmern, Schiller and Polly Blue Eyes
- 2007: Undine Award – Best Young Actor (feature film) for the performance in Eight Miles High
- 2007: Bambi Award – Film – National – Male
- 2009: Golden Camera – Best German Actor for the performance in The Author of Himself: The Life of Marcel Reich-Ranicki
- 2010: Jupiter Award – Best Male Actor (TV) for his performance in The Author of Himself: The Life of Marcel Reich-Ranicki
- 2011: GQ Man of the Year – Film National
|2011||What a Man||Yes||Yes||Yes|
|2013||Break Up Man||Yes||Yes||No|
|2014||Joy of Fatherhood||Yes||Yes||Yes|
|2017||You Are Wanted||Yes||Yes||No|
|2021||Army of Thieves||Yes||Yes||No|
- 1999: Dr. Stefan Frank, season 4, episode 10, als Ingo
- 2000: Trust Me (Freunde), as Speedy
- 2001: Heart Over Head (Herz im Kopf), as Dirk
- 2002: Die Freunde der Freunde (TV film), as Gregor
- 2002: FeardotCom, as Dieter Schrader
- 2003: Soloalbum (Soloalbum), as Ben
- 2003: Die Klasse von '99, as Felix
- 2004: Baal (TV film), as Baal
- 2004: Cold Spring (Kalter Frühling, TV film), as Ben
- 2004: Off Beat (Kammerflimmern), as Crash
- 2004: Gold – The Tulse Luper Suitcases
- 2005: Schiller (TV film), as Friedrich Schiller
- 2005: Polly Blue Eyes, as Ronny Helske
- 2006: Lulu (TV film), as Jack the Ripper
- 2007: Eight Miles High (Das wilde Leben), as Rainer Langhans
- 2007: Ein spätes Mädchen (TV film), as Felix
- 2007: Fata Morgana, as Daniel
- 2007: Rabbit Without Ears, as Moritz
- 2008: The Red Baron (Der rote Baron), as Manfred von Richthofen
- 2008: The Architect, as Jan Winter
- 2008: Valkyrie, as Lieutenant Herber
- 2009: The Author of Himself: The Life of Marcel Reich-Ranicki (TV film), as Marcel Reich-Ranicki
- 2009: Night Train, as Frankie
- 2009: 12 Paces Without a Head, as Gottfried Michaelsen
- 2009: Rabbit Without Ears 2, as Moritz
- 2010: Friendship!, as Tom
- 2011: What a Man, as Alex Nowak
- 2011: Woman in Love, as Alexander Honk
- 2012: Russian Disco, as Wladimir
- 2013: Break Up Man, as Paul Voigt
- 2013: Frau Ella, as Sascha
- 2013: Kokowääh 2, as himself
- 2014: Joy of Fatherhood, as Felix
- 2015: The Little Prince, as the Fox (German version)
- 2015: The Manny, as Clemens
- 2016: The Most Beautiful Day, as Andi
- 2016: Vier gegen die Bank, as Max
- 2017: The Price, as Jonas
- 2017: You Are Wanted (TV series), as Lukas Franke
- 2018: Hot Dog, as Theo
- 2018: Vielmachglas, as Erik Ruge
- 2018: 100 Things, as Toni Katz
- 2018: Kursk
- 2019: Playmobil: The Movie, as Rex Dasher (German version)
- 2020: Resistance, as Klaus Barbie
- 2021: Army of the Dead, as Ludwig Dieter
- 2021: Army of Thieves, as Ludwig Dieter/Sebastian Schlencht-Wöhnert
- 2022: The Swimmers as Sven
- 2022: Hinterland as Josef Severin
- 2023: Oppenheimer
- 2023: Heart of Stone
- Matthias Schweighöfer at IMDb
- Jochen Kürten (26 August 2007). "Matthias Schweighöfer — mehr als nur gutes Aussehen" [Matthias Schweighöfer — more than just a pretty face]. Deutsche Welle. Retrieved 29 July 2017.
- "About Us". German Garment. Archived from the original on 25 October 2016. Retrieved 29 July 2017.
- "First Germany-made Amazon TV series to star Matthias Schweighöfer". Deutsche Welle. 11 February 2016. Retrieved 29 July 2017.
- Jochen Kürten (16 March 2017). "Neue Amazon-Serie mit Schweighöfer: You Are Wanted" [New Amazon series with Schweighöfer: You Are Wanted]. Deutsche Welle. Retrieved 29 July 2017.
- "Matthias Schweighöfer Interview: Army of the Dead". ScreenRant. 20 May 2021. Retrieved 25 May 2021.
- "Army Of Thieves: Everything We Know About The Army Of The Dead Prequel". ScreenRant. 22 May 2021. Retrieved 25 May 2021.
- Kroll, Justin (31 August 2022). "Milli Vanilli Biopic 'Girl You Know It's True' First-Look Photos Revealed By Leonine Studios". Deadline. Retrieved 20 September 2022.
- Roxborough, Scott (1 September 2022). "Milli Vanilli Biopic Players Revealed in 'Girl You Know It's True' First Look". The Hollywood Reporter. Retrieved 20 September 2022.
- "Und sie lieben sich doch! Eine filmreife Love-Story" [And they love each other! A love story fit for film]. Bild. 24 September 2013. Retrieved 29 July 2017.
- "Matthias Schweighöfer Girlfriend - Dating His Army of Thieves Castmate Ruby O. Fee for over 2 Years!".