In 1866, he was the president of the council which decided to invite a foreign dynasty to rule Romania. In 1871, during the Catargiu conservative government, Epureanu was the Minister of Justice between October 1872 and March 1873. He then switched to the opposition and in 1876, he was a Liberal Prime Minister, but later he switched again to the Conservative Party.
He published Chestia locuitorilor privită din punctul de vedere al Regulamentului organic (1866) and Despre pretinsa rescumpărare a căilor ferate (1879).
- Dimitrie R. Rosetti (1897) Dicționarul contimporanilor, Editura Lito-Tipografiei "Populara"