Mannosylfructose-phosphate synthase

Mannosylfructose-phosphate synthase (EC 2.4.1.246, mannosylfructose-6-phosphate synthase, MFPS) is an enzyme with systematic name GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase.[1] This enzyme catalyses the following chemical reaction

Mannosylfructose-phosphate synthase
Identifiers
EC no.2.4.1.246
CAS no.92480-04-1 (not distinguished from EC 2.4.1.167)
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
GDP-mannose + D-fructose 6-phosphate GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate

This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity.

References

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  1. ^ Torres LL, Salerno GL (September 2007). "A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases". Proceedings of the National Academy of Sciences of the United States of America. 104 (36): 14318–23. doi:10.1073/pnas.0706709104. PMC 1964871. PMID 17728402.
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