Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.[5][6][7]

MTIF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMTIF2, mitochondrial translational initiation factor 2
External IDsOMIM: 603766; MGI: 1924034; HomoloGene: 1840; GeneCards: MTIF2; OMA:MTIF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282118
NM_001282119
NM_001282120
NM_133767

RefSeq (protein)

NP_001269047
NP_001269048
NP_001269049
NP_598528

Location (UCSC)Chr 2: 55.24 – 55.27 MbChr 11: 29.48 – 29.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085760Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020459Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bonner DS, Wiley JE, Farwell MA (Mar 1999). "Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16→p14 by in situ hybridization and with somatic cell hybrids". Cytogenet Cell Genet. 83 (1–2): 80–1. doi:10.1159/000015133. PMID 9925935. S2CID 23290955.
  6. ^ Ma L, Spremulli LL (Feb 1995). "Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA". J Biol Chem. 270 (4): 1859–65. doi:10.1074/jbc.270.4.1859. PMID 7829522.
  7. ^ a b "Entrez Gene: MTIF2 mitochondrial translational initiation factor 2".

Further reading

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