MTIF2

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.

MTIF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRV
Identifiers
Aliases	MTIF2, mitochondrial translational initiation factor 2
External IDs	OMIM: 603766; MGI: 1924034; HomoloGene: 1840; GeneCards: MTIF2; OMA:MTIF2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p16.1 Start 55,236,595 bp End 55,269,347 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A3.3 Start 29,476,408 bp End 29,495,279 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii parietal pleura visceral pleura germinal epithelium epithelium of colon Skeletal muscle tissue of biceps brachii tibia right ventricle rectum jejunum Top expressed in tail of embryo myocardium of ventricle genital tubercle plantaris muscle cardiac muscle tissue of left ventricle brown adipose tissue digastric muscle medial ganglionic eminence soleus muscle right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding translation factor activity, RNA binding translation initiation factor activity ribosomal small subunit binding RNA binding GTPase activity Cellular component intracellular anatomical structure mitochondrion nucleoplasm Biological process translational initiation ribosome disassembly protein biosynthesis regulation of translational initiation mitochondrial translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4528 76784 Ensembl ENSG00000085760 ENSMUSG00000020459 UniProt P46199 Q6P1N2 Q91YJ5 RefSeq (mRNA) NM_001005369 NM_002453 NM_001321001 NM_001321002 NM_001321003 NM_001321004 NM_001321005 NM_001282118 NM_001282119 NM_001282120 NM_133767 RefSeq (protein) NP_001005369 NP_001307930 NP_001307931 NP_001307932 NP_001307933 NP_001307934 NP_002444 NP_001005369.1 NP_002444.2 NP_001269047 NP_001269048 NP_001269049 NP_598528 Location (UCSC) Chr 2: 55.24 – 55.27 Mb Chr 11: 29.48 – 29.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Overman RG, Enderle PJ, Farrow JM, et al. (2003). "The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene". Biochim. Biophys. Acta. 1628 (3): 195–205. doi:10.1016/s0167-4781(03)00144-1. PMID 12932832.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Miura E, Kato Y, Matsushima R, et al. (2007). "The Balance between Protein Synthesis and Degradation in Chloroplasts Determines Leaf Variegation in Arabidopsis yellow variegated Mutants". Plant Cell. 19 (4): 1313–28. doi:10.1105/tpc.106.049270. PMC 1913758. PMID 17416734.