Open main menu

Mitochondrially encoded 16S RNA (often abbreviated as 16S) is a mitochondrial ribosomal RNA (rRNA)[1][2] that in humans is encoded by the MT-RNR2 gene. The MT-RNR2 gene also encodes the Humanin polypeptide that has been the target of Alzheimer's disease research.[3]

mitochondrially encoded 16S RNA
Identifiers
SymbolMT-RNR2
Alt. symbolsMTRNR2
NCBI gene4550
HGNC7471
UniProtQ8IVG9
Other data
LocusChr. MT [1]
Location of the MT-RNR2 gene on the H strand of the human mitochondrial genome. MT-RNR2, or RRNL, is one of the two mitochondrial ribosomal RNA genes (blue boxes).

The 16S rRNA is the mitochondrial homologue of the prokaryotic 23S and eukaryotic nuclear 28S ribosomal RNAs.[4]

See alsoEdit

ReferencesEdit

  1. ^ Noda R, Kim CG, Takenaka O, Ferrell RE, Tanoue T, Hayasaka I, et al. (2001). "Mitochondrial 16S rRNA sequence diversity of hominoids". The Journal of Heredity. 92 (6): 490–6. doi:10.1093/jhered/92.6.490. PMID 11948216.
  2. ^ Nagy A, Wilhelm M, Kovacs G (February 2003). "Mutations of mtDNA in renal cell tumours arising in end-stage renal disease". The Journal of Pathology. 199 (2): 237–42. doi:10.1002/path.1273. PMID 12533837.
  3. ^ Tajima H, Niikura T, Hashimoto Y, Ito Y, Kita Y, Terashita K, et al. (May 2002). "Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults". Neuroscience Letters. 324 (3): 227–31. doi:10.1016/S0304-3940(02)00199-4. PMID 12009529.
  4. ^ Eperon IC, Anderson S, Nierlich DP (July 1980). "Distinctive sequence of human mitochondrial ribosomal RNA genes". Nature. 286 (5772): 460–7. Bibcode:1980Natur.286..460E. doi:10.1038/286460a0. PMID 6157106.