Open main menu

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.[5][6]

MRPL37
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDsMGI: 1926268 HomoloGene: 9536 GeneCards: MRPL37
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MRPL37
Genomic location for MRPL37
Band1p32.3Start54,184,041 bp[1]
End54,225,464 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016491
NM_001330602

NM_025500

RefSeq (protein)

NP_001317531
NP_057575

NP_079776

Location (UCSC)Chr 1: 54.18 – 54.23 MbChr 4: 107.06 – 107.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116221 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028622 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.
  6. ^ a b "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".

Further readingEdit