MOTB or MotB can refer to:
- Neverwinter Nights 2: Mask of the Betrayer, a 2007 video game
- Motility protein B, a bacterial protein
- motB, the gene that encodes the protein
- Museum of the Bible, a history museum in Washington, D.C., U.S.
- Mark of the beast, in Christianity
- Mutiny on the Bounty (band)
This disambiguation page lists articles associated with the title MOTB.
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