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MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.[5][6]

MKNK1
Protein MKNK1 PDB 2hw6.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMKNK1, MNK1, MAP kinase interacting serine/threonine kinase 1, MAPK interacting serine/threonine kinase 1
External IDsOMIM: 606724 MGI: 894316 HomoloGene: 37838 GeneCards: MKNK1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MKNK1
Genomic location for MKNK1
Band1p33Start46,557,408 bp[1]
End46,616,843 bp[1]
RNA expression pattern
PBB GE MKNK1 209467 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135553
NM_003684
NM_198973

NM_001285487
NM_001285488
NM_021461
NM_001355174
NM_001369238

RefSeq (protein)

NP_001129025
NP_003675
NP_945324

NP_001272416
NP_001272417
NP_067436
NP_001342103
NP_001356167

Location (UCSC)Chr 1: 46.56 – 46.62 MbChr 4: 115.84 – 115.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

InteractionsEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079277 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028708 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fukunaga R, Hunter T (Jun 1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795. PMID 9155018.
  6. ^ "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1".
  7. ^ Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017.
  8. ^ Pyronnet, S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. ENGLAND. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMC 1171121. PMID 9878069.

Further readingEdit