MIR1250 (gene)

MicroRNA 1250 is a protein that in humans is encoded by the MIR1250 gene.

MIR1250
Identifiers
Aliases	MIR1250, MIRN1250, hsa-mir-1250, mir-1250, microRNA 1250
External IDs	GeneCards: MIR1250; OMA:MIR1250 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 81,133,196 bp End 81,133,308 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum blood pituitary gland body of pancreas anterior pituitary olfactory zone of nasal mucosa right frontal lobe prefrontal cortex Brodmann area 9 granulocyte n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100302229 n/a Ensembl ENSG00000221025 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 17: 81.13 – 81.13 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.