MICAL1

NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene.

MICAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYL, 2CO8
Identifiers
Aliases	MICAL1, MICAL, MICAL-1, NICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1
External IDs	OMIM: 607129 MGI: 2385847 HomoloGene: 11246 GeneCards: MICAL1
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B1 Start 41,352,310 bp End 41,363,028 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery left coronary artery canal of the cervix spleen left uterine tube popliteal artery ganglionic eminence stromal cell of endometrium right lung ascending aorta Top expressed in ascending aorta external carotid artery intestinal villus internal carotid artery fossa Paneth cell sciatic nerve condyle aortic valve trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding oxidoreductase activity actin binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen FAD binding protein binding metal ion binding protein kinase binding monooxygenase activity NAD(P)H oxidase H2O2-forming activity actin filament binding Cellular component cytoplasm cytoskeleton intermediate filament hippocampal mossy fiber expansion cytosol midbody intercellular bridge plasma membrane actin cytoskeleton Biological process negative regulation of protein phosphorylation actin filament depolymerization sulfur oxidation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process cytoskeleton organization signal transduction regulation of regulated secretory pathway blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64780 171580 Ensembl n/a ENSMUSG00000019823 UniProt Q8TDZ2 Q8VDP3 RefSeq (mRNA) NM_022765 NM_001159291 NM_001286613 NM_001164433 NM_138315 NM_001358838 NM_001358839 RefSeq (protein) NP_001152763 NP_001273542 NP_073602 NP_001157905 NP_612188 NP_001345767 NP_001345768 Location (UCSC) n/a Chr 10: 41.35 – 41.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MICAL1 has been shown to interact with NEDD9 and RAB1A.

Further reading

• Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). "Beta 1-integrin-mediated cell signaling in T lymphocytes". J. Dermatol. Sci. 23 (2): 75–86. doi:10.1016/S0923-1811(99)00096-1. PMID 10808124.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Terman JR, Mao T, Pasterkamp RJ, et al. (2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Weide T, Teuber J, Bayer M, Barnekow A (2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. PMID 12788069.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
• Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMC 1079803. PMID 15796781.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Jin X, Zhang J, Dai H, et al. (2007). "Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain". Biophys. Chem. 129 (2–3): 269–78. doi:10.1016/j.bpc.2007.06.008. PMID 17662518.