Major facilitator superfamily domain containing 5 is an atypical SLC expressed in neuronal plasma membrane.[5] It is a plausible Solute carrier transporter.[6] It transports molybdate anions,[7] and it interacts with GLP-1R.[8]

MFSD5
Identifiers
AliasesMFSD5, hsMOT2, major facilitator superfamily domain containing 5, SLC61A1
External IDsMGI: 2145901; HomoloGene: 69517; GeneCards: MFSD5; OMA:MFSD5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001170790
NM_032889

NM_134100

RefSeq (protein)

NP_001164261
NP_116278

NP_598861

Location (UCSC)Chr 12: 53.25 – 53.25 MbChr 15: 102.19 – 102.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MFSD5 belongs to AMTF6.[9]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182544Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045665Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
  6. ^ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  7. ^ Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.
  8. ^ Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.
  9. ^ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.