NADP-dependent malic enzyme is a protein that in humans is encoded by the ME1 gene.[5][6]

ME1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesME1, HUMNDME, MES, malic enzyme 1
External IDsOMIM: 154250; MGI: 97043; HomoloGene: 134785; GeneCards: ME1; OMA:ME1 - orthologs
EC number1.1.1.40
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002395

NM_001198933
NM_008615

RefSeq (protein)

NP_002386

NP_001185862
NP_032641

Location (UCSC)Chr 6: 83.21 – 83.43 MbChr 9: 86.46 – 86.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate to pyruvate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065833Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032418Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Loeber G, Dworkin MB, Infante A, Ahorn H (Jun 1994). "Characterization of cytosolic malic enzyme in human tumor cells". FEBS Lett. 344 (2–3): 181–6. doi:10.1016/0014-5793(94)00386-6. PMID 8187880. S2CID 41426196.
  6. ^ a b "Entrez Gene: ME1 malic enzyme 1, NADP(+)-dependent, cytosolic".

Further reading

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