Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[5][6]

MCC
Identifiers
AliasesMCC, MCC1, mutated in colorectal cancers, WNT signaling pathway regulator, MCC regulator of WNT signaling pathway
External IDsOMIM: 159350; MGI: 96930; HomoloGene: 20539; GeneCards: MCC; OMA:MCC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001085377
NM_002387

NM_001033406
NM_001085373
NM_001085374

RefSeq (protein)

NP_001078846
NP_002378

n/a

Location (UCSC)Chr 5: 113.02 – 113.49 MbChr 18: 44.56 – 44.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171444Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071856Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science. 251 (4999): 1366–70. Bibcode:1991Sci...251.1366K. doi:10.1126/science.1848370. PMID 1848370. S2CID 40048385.
  6. ^ a b "Entrez Gene: MCC mutated in colorectal cancers".

Further reading

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