MAN2B2

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Epididymis-specific alpha-mannosidase is an enzyme that in humans is encoded by the MAN2B2 gene.^[5]^[6]^[7]

MAN2B2

Identifiers

MAN2B2, mannosidase alpha class 2B member 2, EpMAN

External IDs

MGI: 1195262; HomoloGene: 7411; GeneCards: MAN2B2; OMA:MAN2B2 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p16.1	Start	6,575,189 bp^[1]
Band	4p16.1	End	6,623,362 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 B3	Start	36,964,265 bp^[2]
Band	5\|5 B3	End	36,987,997 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

stromal cell of endometrium

Descending thoracic aorta

right coronary artery

ascending aorta

decidua

parotid gland

synovial joint

popliteal artery

tibial arteries

Top expressed in

spermatocyte

spermatid

granulocyte

epithelium of small intestine

yolk sac

stroma of bone marrow

seminiferous tubule

tail of embryo

ileum

primary visual cortex

More reference expression data


More reference expression data

Gene ontology
Molecular function	catalytic activity hydrolase activity alpha-mannosidase activity metal ion binding hydrolase activity, acting on glycosyl bonds carbohydrate binding mannan endo-1,6-alpha-mannosidase activity
Cellular component	extracellular region extracellular exosome lysosomal lumen extracellular space vacuolar membrane
Biological process	metabolism mannose metabolic process protein deglycosylation oligosaccharide catabolic process carbohydrate metabolic process
Sources:Amigo / QuickGO

Species

Human

Mouse


23324


17160


ENSG00000013288


ENSMUSG00000029119


Q9Y2E5


O54782

RefSeq (mRNA)


NM_001292038 NM_015274


NM_008550

RefSeq (protein)


NP_001278967 NP_056089


NP_032576

Location (UCSC)

Chr 4: 6.58 – 6.62 Mb

Chr 5: 36.96 – 36.99 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Epididymis-specific alpha-mannosidase precursor

Mannosidase alpha class 2B member

core-specific lysosomal alpha-1,6-Mannosidase

epididymis-specific alpha-mannosidase

mannosidase, alpha, class 2B, member

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013288 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029119 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
^ Park C, Meng L, Stanton LH, Collins RE, Mast SW, Yi X, Strachan H, Moremen KW (Oct 2005). "Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism". J Biol Chem. 280 (44): 37204–16. doi:10.1074/jbc.M508930200. PMC 1351102. PMID 16115860.
^ "Entrez Gene: MAN2B2 mannosidase, alpha, class 2B, member 2".

Further reading

Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–90. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211. S2CID 13576808.
Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–82. doi:10.1016/0042-6822(92)90331-I. PMID 1736542.
Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi:10.7883/yoken1952.43.75. PMID 2283726.
Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". J. Biol. Chem. 265 (18): 10373–82. doi:10.1016/S0021-9258(18)86956-3. PMID 2355006.
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699. PMID 2542563.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347. PMID 8093218.
Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi:10.1097/00042560-199607000-00001. PMID 8673525.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/jvi.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.
Hiramoto S, Tamba M, Kiuchi S, et al. (1998). "Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia". Biochem. Biophys. Res. Commun. 241 (2): 439–45. doi:10.1006/bbrc.1997.7768. PMID 9425289.
Jin YZ, Dacheux F, Dacheux JL, et al. (1999). "Purification and properties of major alpha-D-mannosidase in the luminal fluid of porcine epididymis". Biochim. Biophys. Acta. 1432 (2): 382–92. doi:10.1016/S0167-4838(99)00117-X. PMID 10407159.

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