MAGI2

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.

MAGI2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UEP, 1UEQ, 1UEW, 1UJV, 1WFV
Identifiers
Aliases	MAGI2, ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM, membrane associated guanylate kinase, WW and PDZ domain containing 2, NPHS15
External IDs	OMIM: 606382 MGI: 1354953 HomoloGene: 8189 GeneCards: MAGI2
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.11 Start 78,017,055 bp End 79,453,667 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 A3 Start 19,432,034 bp End 20,909,790 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum Brodmann area 23 middle temporal gyrus glomerulus metanephric glomerulus Brodmann area 46 parietal lobe entorhinal cortex postcentral gyrus Top expressed in primary motor cortex cingulate gyrus substantia nigra Region I of hippocampus proper nucleus accumbens globus pallidus sciatic nerve arcuate nucleus superior colliculus superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity SMAD binding phosphatase binding beta-1 adrenergic receptor binding molecular adaptor activity type II activin receptor binding signaling receptor complex adaptor activity protein binding activin receptor binding kinase activity Cellular component late endosome cytoplasm synapse cell junction nucleus neuron projection postsynaptic density membrane dendrite perinuclear region of cytoplasm slit diaphragm bicellular tight junction plasma membrane endosome protein-containing complex cell-cell junction Biological process receptor clustering negative regulation of cell population proliferation positive regulation of neuron projection development neuroligin clustering involved in postsynaptic membrane assembly signal transduction negative regulation of activin receptor signaling pathway nerve growth factor signaling pathway planar cell polarity pathway involved in axis elongation SMAD protein signal transduction positive regulation of receptor internalization protein heterooligomerization negative regulation of protein kinase B signaling nervous system development glomerular visceral epithelial cell development positive regulation of synaptic vesicle clustering cellular response to nerve growth factor stimulus positive regulation of phosphoprotein phosphatase activity negative regulation of cell migration positive regulation of signal transduction phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9863 50791 Ensembl ENSG00000187391 ENSMUSG00000040003 UniProt Q86UL8 Q9WVQ1 RefSeq (mRNA) NM_001301128 NM_012301 NM_001170745 NM_001170746 NM_015823 RefSeq (protein) NP_001288057 NP_036433 NP_001164216 NP_001164217 NP_056638 Location (UCSC) Chr 7: 78.02 – 79.45 Mb Chr 5: 19.43 – 20.91 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.

Interactions

MAGI2 has been shown to interact with ATN1 and PTEN (gene).

Further reading

• Wood JD, Yuan J, Margolis RL, et al. (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693. S2CID 20003277.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Ide N, Hata Y, Deguchi M, et al. (1999). "Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin". Biochem. Biophys. Res. Commun. 256 (3): 456–61. doi:10.1006/bbrc.1999.0364. PMID 10080919.
• Wu X, Hepner K, Castelino-Prabhu S, et al. (2000). "Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4233–8. Bibcode:2000PNAS...97.4233W. doi:10.1073/pnas.97.8.4233. PMC 18208. PMID 10760291.
• Xu J, Paquet M, Lau AG, et al. (2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95". J. Biol. Chem. 276 (44): 41310–7. doi:10.1074/jbc.M107480200. PMID 11526121.
• Vazquez F, Grossman SR, Takahashi Y, et al. (2002). "Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex". J. Biol. Chem. 276 (52): 48627–30. doi:10.1074/jbc.C100556200. PMID 11707428.
• Nishimura W, Yao I, Iida J, et al. (2002). "Interaction of synaptic scaffolding molecule and Beta -catenin". J. Neurosci. 22 (3): 757–65. doi:10.1523/JNEUROSCI.22-03-00757.2002. PMC 6758496. PMID 11826105.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yap CC, Muto Y, Kishida H, et al. (2003). "PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein". Biochem. Biophys. Res. Commun. 301 (4): 1122–8. doi:10.1016/S0006-291X(03)00070-6. PMID 12589829.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Evgrafov OV, Mersiyanova I, Irobi J, et al. (2004). "Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy". Nat. Genet. 36 (6): 602–6. doi:10.1038/ng1354. PMID 15122254.
• Franklin JL, Yoshiura K, Dempsey PJ, et al. (2005). "Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein". Exp. Cell Res. 303 (2): 457–70. doi:10.1016/j.yexcr.2004.10.007. PMID 15652357.
• Hu Y, Li Z, Guo L, et al. (2007). "MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells". Arch. Biochem. Biophys. 467 (1): 1–9. doi:10.1016/j.abb.2007.07.027. PMID 17880912.