MAGEA10 (MAGE family member A10) is a protein-coding gene in humans clustered at chromosomal location Xq28. [5]

MAGEA10
Identifiers
AliasesMAGEA10, CT1.10, MAGE10, MAGE family member A10
External IDsOMIM: 300343; MGI: 3588211; HomoloGene: 121621; GeneCards: MAGEA10; OMA:MAGEA10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021048
NM_001011543
NM_001251828

NM_001085506

RefSeq (protein)

NP_001011543
NP_001238757
NP_066386

NP_001078975

Location (UCSC)Chr X: 152.13 – 152.14 MbChr X: 71.43 – 71.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124260Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043453Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MAGE family member A10". Retrieved 2017-06-15.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.