Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene .[5] [6] [7]
This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.[7]
References
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^ a b c GRCh38: Ensembl release 89: ENSG00000179632 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022553 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . ^ Pluta K, Lefebvre O, Martin NC, Smagowicz WJ, Stanford DR, Ellis SR, Hopper AK, Sentenac A, Boguta M (Jul 2001). "Maf1p, a Negative Effector of RNA Polymerase III in Saccharomyces cerevisiae" . Mol Cell Biol . 21 (15): 5031–40. doi :10.1128/MCB.21.15.5031-5040.2001 . PMC 87229 PMID 11438659 . ^ a b "Entrez Gene: MAF1 MAF1 homolog (S. cerevisiae)" .
Further reading
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Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3491–6. Bibcode :2000PNAS...97.3491D . doi :10.1073/pnas.97.7.3491 PMC 16267 PMID 10737800 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Upadhya R, Lee J, Willis IM (2003). "Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription" . Mol. Cell . 10 (6): 1489–94. doi :10.1016/S1097-2765(02)00787-6 PMID 12504022 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases" . Mol. Cell . 26 (3): 367–79. doi :10.1016/j.molcel.2007.03.021 PMID 17499043 . Rollins J, Veras I, Cabarcas S, et al. (2007). "Human Maf1 negatively regulates RNA Polymerase III transcription via the TFIIB family members Brf1 and Brf2" . Int. J. Biol. Sci . 3 (5): 292–302. doi :10.7150/ijbs.3.292 . PMC 1865091 PMID 17505538 .
