Luisa de Medrano (9 August 1484–1527), was a Spanish scholar.
She was born to Diego López de Medrano and Magdalena Bravo de Lagunas. She taught in Latin at the University of Salamanca, and replaced Antonio de Nebrija. She wrote poems and philosophy, though her work has been lost.
The secondary school in Salamanca, IES Lucia de Medrano was named after her.
- Pedro de Torres: Cronicón, Salamanca, 1508.