Club Santos Laguna has had a total of twenty coaches throughout their history in the Primera División, the coach varies in its functions implemented in the football section, responsible for study, plan, assess and evaluate the players. The club has had multiple service coaches, most of them Mexican nationals have been sixteen, counting ten times the services of foreign coaches five Argentines, two Uruguayans, Chilean, a Honduran and a Portuguese.
List of managers edit
| Name | Período | G | W | D | L | GF | GA | DIF | % |
 Carlos Ortiz
|
1988-89 – 1989-90 | 50 | 8 | 26 | 16 | 46 | 71 | -25 | 42% |
| Diego Malta
|
1988–89 | 7 | 0 | 3 | 4 | 4 | 11 | -7 | 21.43% |
| Rubén Maturano
|
1989–90 1991–92 |
73 | 22 | 22 | 29 | 80 | 99 | -19 | 45.21% |
 José de la Paz Herrera
|
1990–91 | 2 | 0 | 0 | 2 | 1 | 4 | -3 | 0% |
| José Luis Estrada
|
1990–91 | 20 | 3 | 3 | 14 | 15 | 30 | -15 | 22.5% |
 Roberto Matosas
|
1990–91 1992–93 |
34 | 8 | 14 | 12 | 34 | 53 | -19 | 44.12% |
| Ignacio Jáuregui
|
1991–92 | 7 | 2 | 1 | 4 | 6 | 11 | -5 | 35.71% |
 Pedro Dellacha
|
1992–93 | 7 | 1 | 2 | 4 | 7 | 10 | -3 | 28.57% |
 Pedro García
|
1992-93 – 1994-95 | 69 | 24 | 20 | 25 | 88 | 101 | -13 | 49.28% |
| Martín Ibacherre
|
1994–95 | 7 | 1 | 2 | 4 | 13 | 17 | -4 | 28.57% |
| Miguel Ángel López
|
1994–95 Invierno 1998 |
37 | 14 | 11 | 12 | 63 | 55 | 8 | 56.92% |
| Patricio Hernández
|
1995–96 | 30 | 8 | 10 | 12 | 36 | 35 | 1 | 37.78% |
| José Vantolrá
|
1995–96 | 3 | 0 | 1 | 2 | 4 | 6 | -2 | 11.11% |
| Alfredo Tena
|
1995-96 – Verano 1998 | 93 | 37 | 23 | 33 | 130 | 134 | -4 | 48.03% |
| Juan de Dios Castillo
|
Invierno 1998 – Invierno 1999 | 40 | 17 | 6 | 17 | 74 | 79 | -5 | 47.5% |
| Fernando Quirarte
|
Invierno 1999 – Verano 2002 | 131 | 58 | 33 | 40 | 249 | 210 | 39 | 52.67% |
| Sergio Bueno
|
Apertura 2002 Clausura 2009 – Apertura 2009 |
36 | 13 | 10 | 13 | 50 | 50 | 0 | 45.37% |
| Luis Fernando Tena
|
Apertura 2002 – Apertura 2003 | 56 | 24 | 16 | 16 | 106 | 85 | 21 | 52.38% |
| Eduardo de la Torre
|
Clausura 2004 – Apertura 2005 | 84 | 30 | 20 | 34 | 138 | 131 | 7 | 43.65% |
| Jorge Vantolrá
|
Apertura 2005 | 3 | 1 | 0 | 2 | 7 | 9 | -2 | 33.33% |
| Benjamín Galindo
|
Clausura 2006 Apertura 2011 – Apertura 2012 |
77 | 38 | 19 | 20 | 144 | 101 | 43 | 57.58% |
| Wilson Graniolatti
|
Clausura 2006 – Apertura 2006 | 17 | 3 | 8 | 6 | 21 | 29 | -8 | 33.33% |
| Daniel Guzmán
|
Apertura 2006 – Clausura 2009 | 120 | 46 | 42 | 32 | 191 | 151 | 40 | 50% |
| Rubén Omar Romano
|
Bicentenario 2010 – Clausura 2011 | 64 | 32 | 14 | 18 | 115 | 83 | 32 | 57.29% |
| Diego Cocca
|
Clausura 2011 – Apertura 2011 | 22 | 8 | 2 | 12 | 36 | 36 | 0 | 39.39% |
| Eduardo Rergis
|
Apertura 2011 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 33.33% |
 Pedro Caixinha
|
Clausura 2013 – Act. | 83 | 36 | 26 | 21 | 136 | 109 | 27 | 53.82% |