This is a list of films which have placed number one at the weekend box office in Ecuador during 2012.
| # | Date | Film | Gross | Notes |
|---|---|---|---|---|
| 1 | January 8, 2012 | Sherlock Holmes: A Game of Shadows | $734,121 | |
| 2 | January 15, 2012 | The Adventures of Tintin: The Secret of the Unicorn | $587,425 | |
| 3 | January 22, 2012 | The Muppets | $754,445 | |
| 4 | January 29, 2012 | $480,867 | ||
| 5 | February 5, 2012 | $414,293 | ||
| 6 | February 12, 2012 | Star Wars: Episode I – The Phantom Menace | $483,252 | |
| 7 | February 19, 2012 | Journey 2: The Mysterious Island | $680,042 | |
| 8 | February 26, 2012 | $612,648 | ||
| 9 | March 4, 2012 | $704,570 | ||
| 10 | March 11, 2012 | John Carter | $690,604 | |
| 11 | March 18, 2012 | $590,056 | ||
| 12 | March 25, 2012 | Beauty and the Beast | $691,550 | |
| 13 | April 1, 2012 | $591,776 | ||
| 14 | April 8, 2012 | The Lorax | $733,874 | |
| 15 | April 15, 2012 | $372,959 | ||
| 16 | April 22, 2012 | Wrath of the Titans | $702,420 | |
| 17 | April 29, 2012 | Marvel's The Avengers | $1,481,899 | |
| 18 | May 6, 2012 | $1,089,452 | ||
| 19 | May 13, 2012 | $676,188 | ||
| 20 | May 20, 2012 | $612,206 | ||
| 21 | May 27, 2012 | Men in Black 3 | $817,882 | |
| 22 | June 3, 2012 | Madagascar 3: Europe's Most Wanted | $854,973 | |
| 23 | June 10, 2012 | $854,511 | ||
| 24 | June 17, 2012 | $831,355 | ||
| 25 | June 24, 2012 | $747,630 | ||
| 26 | July 1, 2012 | Ice Age: Continental Drift | $1,212,422 | |
| 27 | July 8, 2012 | The Amazing Spider-Man | $1,226,712 | |
| 28 | July 15, 2012 | Ice Age: Continental Drift | $982,999 | |
| 29 | July 22, 2012 | $737,202 | ||
| 30 | July 29, 2012 | The Dark Knight Rises | $923,464 | |
| 31 | August 5, 2012 | $703,369 | ||
| 32 | August 12, 2012 | Brave | $1,039,703 | |
| 33 | August 19, 2012 | $634,283 | ||
| 34 | August 26, 2012 | $514,020 | ||
| 35 | September 2, 2012 | Secret of the Wings | $562,726 | |
| 36 | September 9, 2012 | The Apparition | $158,548 | |
| 37 | September 16, 2012 | Resident Evil: Retribution | $655,676 | |
| 38 | September 23, 2012 | $594,522 | ||
| 39 | September 30, 2012 | $479,571 | ||
| 40 | October 7, 2012 | Taken 2 | $469,391 | |
| 41 | October 14, 2012 | Frankenweenie | $663,901 | |
| 42 | October 21, 2012 | Hotel Transylvania | $604,777 | |
| 43 | October 28, 2012 | $575,235 | ||
| 44 | November 4, 2012 | Skyfall | $800,935 | |
| 45 | November 11, 2012 | $487,854 | ||
| 46 | November 18, 2012 | The Twilight Saga: Breaking Dawn – Part 2 | $1,003,809 | |
| 47 | November 25, 2012 | $624,011 | ||
| 48 | December 2, 2012 | Rise of the Guardians | $537,875 | |
| 49 | December 9, 2012 | $481,455 | ||
| 50 | December 16, 2012 | $213,412 | ||
| 51 | December 23, 2012 | Life of Pi | $420,130 | |
| 52 | December 30, 2012 | The Hobbit: An Unexpected Journey | $622,193 |