Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene (Ly-1 antibody reactive clone).[5]

LYAR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLYAR, ZC2HC2, ZLy1 antibody reactive
External IDsOMIM: 617684; MGI: 107470; HomoloGene: 41200; GeneCards: LYAR; OMA:LYAR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145725
NM_017816

NM_025281

RefSeq (protein)

NP_001139197
NP_060286

NP_079557

Location (UCSC)Chr 4: 4.27 – 4.29 MbChr 5: 38.38 – 38.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LYAR contains a zinc finger motif and three copies of nuclear localization signals. LYAR is mainly localized to the nucleoli. LYAR is present at high levels in early embryos and preferentially in the liver fetal thymus.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145220Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067367Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: LYAR hypothetical protein FLJ20425".
  6. ^ Su L, Hershberger RJ, Weissman IL (May 1993). "LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation". Genes Dev. 7 (5): 735–48. doi:10.1101/gad.7.5.735. PMID 8491376.

Further reading

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