LUC7L

Putative RNA-binding protein Luc7-like 1 is a protein that in humans is encoded by the LUC7L gene.

LUC7L
Identifiers
Aliases	LUC7L, LUC7-LIKE, LUC7B1, Luc7, SR+89, hLuc7B1, LUC7 like
External IDs	OMIM: 607782 MGI: 1914228 HomoloGene: 100558 GeneCards: LUC7L
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 188,969 bp End 229,463 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A3.3|17 13.09 cM Start 26,471,870 bp End 26,504,478 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve anterior pituitary left lobe of thyroid gland right lobe of thyroid gland cerebellar hemisphere right uterine tube canal of the cervix body of pancreas ganglionic eminence left uterine tube Top expressed in abdominal wall medullary collecting duct facial motor nucleus morula ventromedial nucleus substantia nigra maxillary prominence arcuate nucleus neural tube lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RS domain binding protein binding mRNA binding identical protein binding Cellular component U1 snRNP U2-type prespliceosome nucleus Biological process mRNA splice site selection negative regulation of striated muscle tissue development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55692 66978 Ensembl ENSG00000007392 ENSMUSG00000024188 UniProt Q9NQ29 Q1W6G4 Q9CYI4 RefSeq (mRNA) NM_018032 NM_201412 NM_001320226 NM_001330420 NM_025881 NM_028190 RefSeq (protein) NP_001307155 NP_001317349 NP_060502 NP_958815 NP_060502.1 NP_001307155.1 NP_080157 NP_082466 Location (UCSC) Chr 16: 0.19 – 0.23 Mb Chr 17: 26.47 – 26.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Tufarelli C, Frischauf AM, Hardison R, et al. (2001). "Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain". Genomics. 71 (3): 307–14. doi:10.1006/geno.2000.6394. PMID 11170747.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.