LRIT3

Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 is a protein that in humans is encoded by the LRIT3 gene.

LRIT3
Identifiers
Aliases	LRIT3, CSNB1F, FIGLER4, leucine-rich repeat, Ig-like and transmembrane domains 3, leucine rich repeat, Ig-like and transmembrane domains 3
External IDs	OMIM: 615004 MGI: 2685267 HomoloGene: 19426 GeneCards: LRIT3
Gene location (Human) Chr. Chromosome 4 (human) Band 4q25 Start 109,848,107 bp End 109,872,315 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G3 Start 129,581,530 bp End 129,597,679 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus cerebellar hemisphere Brodmann area 9 renal cortex tibial nerve skeletal muscle tissue right coronary artery skin of abdomen right lobe of liver kidney Top expressed in secondary oocyte lens renal cortex proximal tubule kidney cerebellar cortex duodenum foregut stomach colon More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 345193 242235 Ensembl ENSG00000183423 ENSMUSG00000093865 UniProt Q3SXY7 W8DXL4 RefSeq (mRNA) NM_198506 NM_001205102 NM_001287224 RefSeq (protein) NP_940908 NP_001274153 Location (UCSC) Chr 4: 109.85 – 109.87 Mb Chr 3: 129.58 – 129.6 Mb PubMed search
Wikidata
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Further reading

• Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (June 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Human Molecular Genetics. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
• Kim SD, Liu JL, Roscioli T, Buckley MF, Yagnik G, Boyadjiev SA, Kim J (May 2012). "Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1". FEBS Letters. 586 (10): 1516–21. doi:10.1016/j.febslet.2012.04.010. PMC 3372856. PMID 22673519.
• Zeitz C, Jacobson SG, Hamel CP, Bujakowska K, Neuillé M, Orhan E, Zanlonghi X, Lancelot ME, Michiels C, Schwartz SB, Bocquet B, Antonio A, Audier C, Letexier M, Saraiva JP, Luu TD, Sennlaub F, Nguyen H, Poch O, Dollfus H, Lecompte O, Kohl S, Sahel JA, Bhattacharya SS, Audo I (January 2013). "Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness". American Journal of Human Genetics. 92 (1): 67–75. doi:10.1016/j.ajhg.2012.10.023. PMC 3542465. PMID 23246293.