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Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.[5][6]

LPP
Identifiers
Aliases LPP, LIM domain containing preferred translocation partner in lipoma
External IDs MGI: 2441849 HomoloGene: 4075 GeneCards: LPP
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for LPP
Genomic location for LPP
Band 3q27.3-q28 Start 188,153,284 bp[1]
End 188,890,671 bp[1]
RNA expression pattern
PBB GE LPP 202821 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001167671
NM_001167672
NM_005578

NM_001145952
NM_001145954
NM_178665

RefSeq (protein)

NP_001161143
NP_001161144
NP_005569

NP_001139424
NP_001139426
NP_848780

Location (UCSC) Chr 3: 188.15 – 188.89 Mb Chr 3: 24.39 – 24.99 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145012 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033306 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ (Feb 1997). "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family". Genomics. 36 (1): 118–29. doi:10.1006/geno.1996.0432. PMID 8812423. 
  6. ^ a b "Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma". 

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.