LPH-5 (drug)

LPH-5 (drug)
Clinical data
ATC code	none;
Legal status
Legal status	In General Unscheduled;
Identifiers
	IUPAC name (S)-3-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)piperidine;
CAS Number	2641630-97-7 ;
PubChem CID	156337168;
Chemical and physical data
Formula	C14H18F3NO2
Molar mass	289.298 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC([C@@]2([H])CNCCC2)=C(OC)C=C1C(F)(F)F;
	InChI InChI=InChI=1S/C14H18F3NO2/c1-19-12-7-11(14(15,16)17)13(20-2)6-10(12)9-4-3-5-18-8-9/h6-7,9,18H,3-5,8H2,1-2H3/t9-/m1/s1; Key:NZKYTYHIERLZBG-SECBINFHSA-N;

LPH-5 is a psychedelic discovered by Emil Ro̷rsted and colleagues at Danish biopharmaceutical company Lophora.^[1] It is a conformationally-restricted derivative of the phenethylamine 2C-TFM, also a hallucinogen, and acts as a potent agonist of the 5-HT_2A receptor (EC₅₀ = 3.2 nM, E_max = 78%).^[2]

References edit

^ Rorsted EM, Jensen AA, Smits G, Frydenvang K, Kristensen JL (April 2024). "Discovery and Structure–Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.4c00082. PMID 38648420.
^ US 2021/0137908, Kristensen JL, Jensen AA, Märcher-Rørsted E, "5-HT2A Agonists for Use in Treatment of Depression.", published 13 May 2021, assigned to Lophora ApS.

Clinical data

ATC code	none
Legal status
Legal status	In General Unscheduled
Identifiers
IUPAC name (S)-3-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)piperidine
CAS Number	2641630-97-7^Y
PubChem CID	156337168
Chemical and physical data
Formula	C₁₄H₁₈F₃NO₂
Molar mass	289.298 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC1=CC([C@@]2([H])CNCCC2)=C(OC)C=C1C(F)(F)F
InChI InChI=InChI=1S/C14H18F3NO2/c1-19-12-7-11(14(15,16)17)13(20-2)6-10(12)9-4-3-5-18-8-9/h6-7,9,18H,3-5,8H2,1-2H3/t9-/m1/s1 Key:NZKYTYHIERLZBG-SECBINFHSA-N