LIMD1

LIM domain-containing protein 1 is a protein that in humans is encoded by the LIMD1 gene.

LIMD1
Identifiers
Aliases	LIMD1, LIM domains containing 1, LIM domain containing 1
External IDs	OMIM: 604543 MGI: 1352502 HomoloGene: 8478 GeneCards: LIMD1
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 45,555,394 bp End 45,686,341 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F4|9 74.0 cM Start 123,307,771 bp End 123,350,617 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung superficial temporal artery retinal pigment epithelium visceral pleura synovial joint pylorus oral cavity germinal epithelium superior surface of tongue secondary oocyte Top expressed in saccule otic placode medullary collecting duct triceps brachii muscle spermatid temporal muscle internal carotid artery external carotid artery sternocleidomastoid muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding transcription corepressor activity zinc ion binding Cellular component cytoplasm RISC complex focal adhesion adherens junction P-body cell junction nucleus transcription regulator complex cytosol plasma membrane cell-cell junction Biological process response to hypoxia regulation of transcription, DNA-templated phosphorylation negative regulation of osteoblast differentiation transcription, DNA-templated positive regulation of gene silencing by miRNA multicellular organism development negative regulation of hippo signaling gene silencing by miRNA cytoskeleton organization P-body assembly regulation of cell shape osteoblast development gene silencing negative regulation of transcription, DNA-templated cell migration negative regulation of canonical Wnt signaling pathway signal transduction regulation of transcription from RNA polymerase II promoter in response to hypoxia Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8994 29806 Ensembl ENSG00000144791 ENSMUSG00000025239 UniProt Q9UGP4 Q9QXD8 RefSeq (mRNA) NM_014240 NM_013860 RefSeq (protein) NP_055055 NP_038888 Location (UCSC) Chr 3: 45.56 – 45.69 Mb Chr 9: 123.31 – 123.35 Mb PubMed search
Wikidata
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Further reading

• Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P." Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
• Kiss H, Kedra D, Kiss C, et al. (2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics. 73 (1): 10–9. doi:10.1006/geno.2000.6498. PMID 11352561.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sharp TV, Munoz F, Bourboulia D, et al. (2004). "LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16531–6. Bibcode:2004PNAS..10116531S. doi:10.1073/pnas.0407123101. PMC 534532. PMID 15542589.
• Feng Y, Longmore GD (2005). "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25.10.4010-4022.2005. PMC 1087715. PMID 15870274.
• Huggins CJ, Gill M, Andrulis IL (2007). "Identification of rare variants in the hLIMD1 gene in breast cancer". Cancer Genet. Cytogenet. 178 (1): 36–41. doi:10.1016/j.cancergencyto.2007.06.007. PMID 17889706.