Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene.[5][6] Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.[7]

LGR6
Identifiers
AliasesLGR6, GPCR, VTS20631, leucine-rich repeat containing G protein-coupled receptor 6, leucine rich repeat containing G protein-coupled receptor 6
External IDsOMIM: 606653; MGI: 2441805; HomoloGene: 49680; GeneCards: LGR6; OMA:LGR6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017403
NM_001017404
NM_021636

NM_001033409

RefSeq (protein)

NP_001017403
NP_001017404
NP_067649

NP_001028581

Location (UCSC)Chr 1: 202.19 – 202.32 MbChr 1: 134.91 – 135.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133067Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042793Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.
  6. ^ a b "Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6".
  7. ^ Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017). "Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma". Nature Genetics. 49 (11): 1624–1632. doi:10.1038/ng.3957. PMC 5662105. PMID 28945253.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.