Legumain is a protein that in humans is encoded by the LGMN gene.[5][6][7]

LGMN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLGMN, AEP, LGMN1, PRSC1, legumain
External IDsOMIM: 602620; MGI: 1330838; HomoloGene: 38075; GeneCards: LGMN; OMA:LGMN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001008530
NM_005606
NM_001363696
NM_001363699

NM_011175
NM_001378875

RefSeq (protein)

NP_001008530
NP_005597
NP_001350625
NP_001350628

NP_035305
NP_001365804

Location (UCSC)Chr 14: 92.7 – 92.75 MbChr 12: 102.36 – 102.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100600Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021190Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tanaka T, Inazawa J, Nakamura Y (Dec 1996). "Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1". Cytogenet Cell Genet. 74 (1–2): 120–3. doi:10.1159/000134397. PMID 8893817.
  6. ^ Chen JM, Dando PM, Rawlings ND, Brown MA, Young NE, Stevens RA, Hewitt E, Watts C, Barrett AJ (Apr 1997). "Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase". J Biol Chem. 272 (12): 8090–8. doi:10.1074/jbc.272.12.8090. PMID 9065484.
  7. ^ a b "Entrez Gene: LGMN legumain".

Further reading

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