Leucine zipper-EF-hand containing transmembrane protein 1 is a protein that in humans is encoded by the LETM1 gene.[5]

LETM1
Identifiers
AliasesLETM1, leucine zipper and EF-hand containing transmembrane protein 1, SLC55A1
External IDsOMIM: 604407; MGI: 1932557; HomoloGene: 56320; GeneCards: LETM1; OMA:LETM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012318

NM_019694

RefSeq (protein)

NP_036450

NP_062668

Location (UCSC)Chr 4: 1.81 – 1.86 MbChr 5: 33.9 – 33.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure

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The LETM1 protein has a transmembrane domain and a casein kinase 2 and protein kinase C phosphorylation site.[6] The LETM1 gene is expressed in the mitochondria of many eukaryotes indicating that this is a conserved mitochondrial protein.[7]

Function

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LETM1 is a eukaryotic protein that is expressed in the inner membrane of mitochondria. Experiments performed with human cells have been interpreted to indicate that it functions as a component of a Ca2+/H+ antiporter.[8] Experimental results with yeast cells have been interpreted as suggesting that LETM1 functions as a component of a K+/H+ antiporter.[9] The Drosophila melanogaster LETM1 protein has been shown to functionally substitute for the K+/H+ antiporter function in yeast cells.[10]

Clinical significance

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Deletion of LETM1 is thought to be involved in the development of Wolf–Hirschhorn syndrome in humans.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168924Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005299Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: leucine zipper-EF-hand containing transmembrane protein 1".
  6. ^ a b Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A (Sep 1999). "LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients". Genomics. 60 (2): 218–25. doi:10.1006/geno.1999.5881. PMID 10486213.
  7. ^ Schlickum S, Moghekar A, Simpson JC, Steglich C, O'Brien RJ, Winterpacht A, Endele SU (Feb 2004). "LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein". Genomics. 83 (2): 254–61. doi:10.1016/j.ygeno.2003.08.013. PMID 14706454.
  8. ^ Waldeck-Weiermair M, Jean-Quartier C, Rost R, Khan MJ, Vishnu N, Bondarenko AI, Imamura H, Malli R, Graier WF (Aug 2011). "Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways". The Journal of Biological Chemistry. 286 (32): 28444–55. doi:10.1074/jbc.M111.244517. PMC 3151087. PMID 21613221.
  9. ^ Zotova L, Aleschko M, Sponder G, Baumgartner R, Reipert S, Prinz M, Schweyen RJ, Nowikovsky K (May 2010). "Novel components of an active mitochondrial K(+)/H(+) exchange". The Journal of Biological Chemistry. 285 (19): 14399–414. doi:10.1074/jbc.M109.059956. PMC 2863244. PMID 20197279.
  10. ^ McQuibban AG, Joza N, Megighian A, Scorzeto M, Zanini D, Reipert S, Richter C, Schweyen RJ, Nowikovsky K (Mar 2010). "A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome". Human Molecular Genetics. 19 (6): 987–1000. doi:10.1093/hmg/ddp563. PMID 20026556.

Further reading

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This article incorporates text from the public domain Pfam and InterPro: IPR011685

This article incorporates text from the United States National Library of Medicine, which is in the public domain.