LCTL

This article is about the protein. For the linguistics term, see Less Commonly Taught Languages.

Lactase-like is a protein that in humans is encoded by the LCTL gene. Lactase-like is a glycosidase enzyme.

LCTL
Identifiers
Aliases	LCTL, KLG, KLPH, lactase like
External IDs	OMIM: 617060 MGI: 2183549 HomoloGene: 70710 GeneCards: LCTL
Gene location (Human) Chr. Chromosome 15 (human) Band 15q22.31 Start 66,547,179 bp End 66,565,998 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 C Start 64,024,429 bp End 64,045,400 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium caudate nucleus nucleus accumbens amygdala putamen substantia nigra Brodmann area 9 prefrontal cortex hypothalamus Top expressed in lens white adipose tissue morula kidney blastocyst ovary secondary oocyte skeletal muscle tissue esophagus zone of skin More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity, hydrolyzing O-glycosyl compounds beta-glucosidase activity Cellular component integral component of membrane endoplasmic reticulum membrane brush border membrane endoplasmic reticulum Biological process glycosyl compound metabolic process carbohydrate metabolic process lens morphogenesis in camera-type eye visual perception response to stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 197021 235435 Ensembl ENSG00000188501 ENSMUSG00000032401 UniProt Q6UWM7 Q8K1F9 RefSeq (mRNA) NM_001278562 NM_207338 NM_001394632 NM_001394633 NM_145835 RefSeq (protein) NP_001265491 NP_997221 NP_665834 Location (UCSC) Chr 15: 66.55 – 66.57 Mb Chr 9: 64.02 – 64.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Further reading

• Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE (December 2011). "Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells". The Journal of Biological Chemistry. 286 (50): 43294–300. doi:10.1074/jbc.M111.267641. PMC 3234855. PMID 22020932.
• Mian IS (June 1998). "Sequence, structural, functional, and phylogenetic analyses of three glycosidase families". Blood Cells, Molecules & Diseases. 24 (2): 83–100. doi:10.1006/bcmd.1998.9998. PMID 9779294.
• Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y (July 2002). "Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1576 (3): 341–5. doi:10.1016/S0167-4781(02)00281-6. PMID 12084582.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.