La-related protein 4 is a protein that in humans is encoded by the LARP4 gene.[4][5] LARP4 is an RNA-binding protein which consists of a La motif (LaM), RNA recognition motif (RRM) and a putative PABP binding motif. It has been shown that LARP4 is involved in mRNA stability.[6]

LARP4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLARP4, PP13296, La ribonucleoprotein domain family member 4
External IDsMGI: 2443114; HomoloGene: 19173; GeneCards: LARP4; OMA:LARP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024526
NM_001080948
NM_001284521
NM_001284522
NM_001284523

RefSeq (protein)

NP_001019697
NP_001074417
NP_001271450
NP_001271451
NP_001271452

Location (UCSC)n/aChr 15: 99.87 – 99.91 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

LARP4 is known to regulate cancer cell migration and invasion by altering cell shape.[7] It is also reported to be a glioma tumor suppressor.[8]

References

edit
  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023025Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  5. ^ "Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".
  6. ^ Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (February 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.
  7. ^ Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (November 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.
  8. ^ Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (April 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.

Further reading

edit