Kynurenine—glyoxylate transaminase

In enzymology, a kynurenine-glyoxylate transaminase (EC 2.6.1.63) is an enzyme that catalyzes the chemical reaction:

kynurenine-glyoxylate transaminase
Identifiers
EC no.2.6.1.63
CAS no.74506-33-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
L-kynurenine + glyoxylate 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine

Thus, the two substrates of this enzyme are L-kynurenine and glyoxylate, whereas its two products are 4-(2-aminophenyl)-2,4-dioxobutanoate and glycine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-kynurenine:glyoxylate aminotransferase (cyclizing). This enzyme is also called kynurenine-glyoxylate aminotransferase.

References

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  • Harada I (1980). "[Glucagen inducible kynurenine aminotransferase.]". Wakayama Igaku. 31: 61–68.