Ubiquitin-conjugating enzyme E2 variant 1, also known as Kua-UEV, is a human gene.[3]

PEDS1-UBE2V1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPEDS1-UBE2V1, CROC-1B, CROC1B, KUA-UEV, Kua-UEV, TMEM189-UBE2V1 readthrough, PEDS1-UBE2V1 readthrough, TMEM189-UBE2V1
External IDsHomoloGene: 100008; GeneCards: PEDS1-UBE2V1; OMA:PEDS1-UBE2V1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003349
NM_199203

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 20: 50.08 – 50.15 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

The Kua-UEV mRNA is an infrequent but naturally occurring co-transcribed product of the neighboring Kua and UBE2V1 genes.[4] Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. Two alternative transcripts encoding different isoforms have been described. The proteins produced by these transcripts have UEV1 B domains but the proteins are localized to the cytoplasm rather than to the nucleus. The significance of these co-transcribed mRNAs and the function of their protein products have not yet been determined.[3]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124208Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1".
  4. ^ Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, et al. (November 2000). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome Research. 10 (11): 1743–56. doi:10.1101/gr.gr-1405r. PMC 310942. PMID 11076860.

Further reading

edit