Kaykhusraw, Kaykhosrow, Kay Khosrow, Kaikhosro, Kaikhosrow, Kai Khusraw, Kay Khusrau, or Kay Khusraw (Persian: کیخسرو) may refer to one of the following persons, named after the legendary Persian warrior Kai Khosrow:
- Kaykhusraw I (died 1211), Seljuq Sultan of Rum
- Kaykhusraw II (died 1246), Seljuq Sultan of Rum
- Kaykhusraw III (died 1284), Seljuq Sultan of Rum
- Kay Khusraw ibn Yazdagird (died 1328), Bavandid king in Mazandaran
- Kaikhosro II Jaqeli (died 1573), atabeg of the Principality of Samtskhe
- Kaikhosro, Prince of Mukhrani (died 1629), prince of the House of Mukhrani
- Kaikhosro I Gurieli (died 1660), member of the House of Gurieli
- Kaikhosro II Gurieli (died 1689), member of the House of Gurieli
- Kaikhosro III Gurieli (died c. 1751), member of the House of Gurieli
- Kaikhosro IV Gurieli (died 1829), member of the House of Gurieli
- Kaikhosro of Kartli (died 1711), Safavid commander-in-chief, Safavid-appointed vali/king of Kartli
- Kaykhosrow Khan (tofangchi-aghasi) (died 1674), commander of the Safavid Empire's musketeer corps
- Kaikhosru Shapurji Sorabji (died 1988), English composer, music critic, and pianist
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