Kynurenine—oxoglutarate transaminase 1 is an enzyme that in humans is encoded by the CCBL1 gene.[4][5] It is one of the Kynurenine—oxoglutarate transaminases.

KYAT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKYAT1, GTK, KAT1, KATI, CCBL1, kynurenine aminotransferase 1
External IDsOMIM: 600547; MGI: 1917516; HomoloGene: 37872; GeneCards: KYAT1; OMA:KYAT1 - orthologs
EC number4.4.1.13
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001122671
NM_001122672
NM_001287390
NM_004059

NM_172404
NM_001356474
NM_001356475

RefSeq (protein)

NP_765992
NP_001343403
NP_001343404

Location (UCSC)n/aChr 2: 30.08 – 30.1 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity.[5]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039648Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Perry S, Harries H, Scholfield C, Lock T, King L, Gibson G, Goldfarb P (Apr 1995). "Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase". FEBS Lett. 360 (3): 277–80. doi:10.1016/0014-5793(95)00123-Q. PMID 7883047. S2CID 83606450.
  5. ^ a b "Entrez Gene: CCBL1 cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)".
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Further reading

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