KSR1

For the KSR1 supercomputer, see Kendall Square Research.

Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene.

KSR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KBE, 1KBF, 2LPE
Identifiers
Aliases	KSR1, KSR, RSU2, kinase suppressor of ras 1
External IDs	OMIM: 601132; MGI: 105051; HomoloGene: 8410; GeneCards: KSR1; OMA:KSR1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 27,456,448 bp End 27,626,438 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 46.74 cM Start 78,904,266 bp End 79,037,233 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas sural nerve oocyte right lobe of thyroid gland canal of the cervix left lobe of thyroid gland gallbladder ectocervix left testis left ovary Top expressed in muscle of thigh temporal muscle triceps brachii muscle dentate gyrus of hippocampal formation granule cell digastric muscle medial head of gastrocnemius muscle sternocleidomastoid muscle quadriceps femoris muscle granulocyte vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein C-terminus binding protein binding ATP binding MAP-kinase scaffold activity protein kinase activity signal transducer activity mitogen-activated protein kinase kinase binding chaperone binding Hsp90 protein binding 14-3-3 protein binding Cellular component cytoplasm cytosol endoplasmic reticulum membrane membrane endoplasmic reticulum cell projection ruffle membrane plasma membrane protein-containing complex Biological process intracellular signal transduction MAPK cascade cAMP-mediated signaling protein phosphorylation Ras protein signal transduction positive regulation of MAPK cascade regulation of cell population proliferation regulation of MAP kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8844 16706 Ensembl ENSG00000141068 ENSMUSG00000018334 UniProt Q8IVT5 Q61097 RefSeq (mRNA) NM_014238 NM_001367810 NM_001394583 NM_001394584 NM_001394585 NM_013571 NM_001348207 RefSeq (protein) NP_055053 NP_001354739 NP_001335136 NP_038599 Location (UCSC) Chr 17: 27.46 – 27.63 Mb Chr 11: 78.9 – 79.04 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Goettel JA, Liang D, Hilliard VC, et al. (2011). "KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1". Exp. Cell Res. 317 (4): 452–63. doi:10.1016/j.yexcr.2010.11.018. PMC 3038243. PMID 21144847.
• Kolesnick R, Xing HR (2004). "Inflammatory bowel disease reveals the kinase activity of KSR1". J. Clin. Invest. 114 (9): 1233–7. doi:10.1172/JCI23441. PMC 524240. PMID 15520853.
• Xing HR, Lozano J, Kolesnick R (2000). "Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras". J. Biol. Chem. 275 (23): 17276–80. doi:10.1074/jbc.C900989199. PMID 10764733.
• Roy F, Therrien M (2002). "MAP kinase module: the Ksr connection". Curr. Biol. 12 (9): R325–7. Bibcode:2002CBio...12.R325R. doi:10.1016/S0960-9822(02)00831-X. PMID 12007434. S2CID 17763459.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matheny SA, Chen C, Kortum RL, et al. (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. Bibcode:2004Natur.427..256M. doi:10.1038/nature02237. PMID 14724641. S2CID 4416552.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim M, Yan Y, Kortum RL, et al. (2005). "Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity". Cancer Res. 65 (10): 3986–92. doi:10.1158/0008-5472.CAN-03-2334. PMID 15899786.
• Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
• Wang X, Wang TT, White JH, Studzinski GP (2006). "Induction of kinase suppressor of RAS-1(KSR-1) gene by1, α25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region". Oncogene. 25 (53): 7078–85. doi:10.1038/sj.onc.1209697. PMC 2843694. PMID 16732322.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.