Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.[5] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.[6]

KLF8
Identifiers
AliasesKLF8, BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDsOMIM: 300286; MGI: 2442430; HomoloGene: 68549; GeneCards: KLF8; OMA:KLF8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173780
NM_001357183

RefSeq (protein)

NP_776141
NP_001344112

Location (UCSC)Chr X: 56.23 – 56.29 MbChr X: 152.02 – 152.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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KLF8 has been shown to interact with CTBP2.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102349Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041649Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: KLF8 Kruppel-like factor 8".
  6. ^ Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018. Retrieved 12 January 2019.
  7. ^ van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

Further reading

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