KLF7

Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene.

KLF7
Identifiers
Aliases	KLF7, UKLF, Kruppel-like factor 7 (ubiquitous), Kruppel like factor 7
External IDs	OMIM: 604865; MGI: 1935151; HomoloGene: 2751; GeneCards: KLF7; OMA:KLF7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.3 Start 207,074,137 bp End 207,167,267 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C2 Start 64,068,606 bp End 64,161,441 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell saphenous vein ganglionic eminence Achilles tendon spinal ganglia bone marrow cells sural nerve gonad hair follicle testicle Top expressed in Rostral migratory stream trigeminal ganglion spinal ganglia supraoptic nucleus lumbar spinal ganglion aortic valve ascending aorta barrel cortex saccule motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription coactivator activity zinc ion binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated axonogenesis transcription, DNA-templated dendrite morphogenesis axon guidance transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of epidermal cell differentiation regulation of insulin secretion negative regulation of adipose tissue development negative regulation of transcription by RNA polymerase II glucose homeostasis negative regulation of insulin secretion involved in cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8609 93691 Ensembl ENSG00000118263 ENSMUSG00000025959 UniProt O75840 Q99JB0 RefSeq (mRNA) NM_001270942 NM_001270943 NM_001270944 NM_003709 NM_033563 RefSeq (protein) NP_001257871 NP_001257872 NP_001257873 NP_003700 NP_291041 Location (UCSC) Chr 2: 207.07 – 207.17 Mb Chr 1: 64.07 – 64.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This protein is a member of the Kruppel-like family of transcription factors.

Further reading

• Cho SY, Park PJ, Shin HJ, et al. (2007). "(-)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells". Am. J. Physiol. Endocrinol. Metab. 292 (4): E1166–72. doi:10.1152/ajpendo.00436.2006. PMID 17164435.
• Kawamura Y, Tanaka Y, Kawamori R, Maeda S (2006). "Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line". Mol. Endocrinol. 20 (4): 844–56. doi:10.1210/me.2005-0138. PMID 16339272.
• Kanazawa A, Kawamura Y, Sekine A, et al. (2005). "Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes". Diabetologia. 48 (7): 1315–22. doi:10.1007/s00125-005-1797-0. PMID 15937668.
• Smaldone S, Laub F, Else C, et al. (2004). "Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity". Mol. Cell. Biol. 24 (3): 1058–69. doi:10.1128/MCB.24.3.1058-1069.2004. PMC 321422. PMID 14729953.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki S, Chuang LF, Doi RH, Chuang RY (2004). "Identification of opioid-regulated genes in human lymphocytic cells by differential display: upregulation of Krüppel-like factor 7 by morphine". Exp. Cell Res. 291 (2): 340–51. doi:10.1016/S0014-4827(03)00408-7. PMID 14644156.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsumoto N, Laub F, Aldabe R, et al. (1998). "Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors". J. Biol. Chem. 273 (43): 28229–37. doi:10.1074/jbc.273.43.28229. PMID 9774444.

External links

• KLF7 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)