Lysine (K)-specific demethylase 1B is a protein that in humans is encoded by the KDM1B gene.[5]

KDM1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDM1B, AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2, lysine demethylase 1B
External IDsOMIM: 613081; MGI: 2145261; HomoloGene: 131158; GeneCards: KDM1B; OMA:KDM1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153042
NM_001364614

NM_172262

RefSeq (protein)

NP_694587
NP_001351543

NP_758466
NP_001389837
NP_001389838

Location (UCSC)Chr 6: 18.16 – 18.22 MbChr 13: 47.2 – 47.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function.[5][6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165097Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038080Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Lysine (K)-specific demethylase 1B".
  6. ^ Karytinos A, Forneris F, Profumo A, Ciossani G, Battaglioli E, Binda C, Mattevi A (Jun 2009). "A novel mammalian flavin-dependent histone demethylase". The Journal of Biological Chemistry. 284 (26): 17775–82. doi:10.1074/jbc.M109.003087. PMC 2719416. PMID 19407342.

Further reading

edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.