KCNK1

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.

KCNK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UKM
Identifiers
Aliases	KCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1, potassium two pore domain channel subfamily K member 1
External IDs	OMIM: 601745 MGI: 109322 HomoloGene: 1691 GeneCards: KCNK1
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.2 Start 233,614,106 bp End 233,672,514 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E2 Start 126,721,909 bp End 126,757,424 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis pons endothelial cell cerebellar hemisphere orbitofrontal cortex corpus epididymis Brodmann area 23 caput epididymis jejunal mucosa inferior ganglion of vagus nerve Top expressed in seminal vesicula molar mucosa of urinary bladder cerebellar vermis submandibular gland pontine nuclei Paneth cell medial vestibular nucleus crypt of lieberkuhn of small intestine anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function sodium channel activity potassium ion leak channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity potassium channel activity protein binding identical protein binding Cellular component cytoplasm integral component of membrane recycling endosome perikaryon endosome cell projection membrane voltage-gated potassium channel complex plasma membrane integral component of plasma membrane synapse inward rectifier potassium channel complex brush border membrane cell junction dendrite potassium channel complex apical plasma membrane cytoplasmic vesicle intracellular membrane-bounded organelle Biological process sodium ion transmembrane transport response to nicotine ion transport potassium ion transport cardiac conduction potassium ion transmembrane transport regulation of resting membrane potential stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3775 16525 Ensembl ENSG00000135750 ENSMUSG00000033998 UniProt O00180 O08581 RefSeq (mRNA) NM_002245 NM_008430 RefSeq (protein) NP_002236 NP_032456 Location (UCSC) Chr 1: 233.61 – 233.67 Mb Chr 8: 126.72 – 126.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes K_2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.

See also

• Tandem pore domain potassium channel

Further reading

• Goldstein SA, Wang KW, Ilan N, Pausch MH (1998). "Sequence and function of the two P domain potassium channels: implications of an emerging superfamily". J. Mol. Med. 76 (1): 13–20. doi:10.1007/s109-1998-8100-0. PMID 9462864.
• Lesage F, Lazdunski M (2000). "Molecular and functional properties of two-pore-domain potassium channels". Am. J. Physiol. Renal Physiol. 279 (5): F793–801. doi:10.1152/ajprenal.2000.279.5.F793. PMID 11053038. S2CID 16605017.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Lesage F, Guillemare E, Fink M, et al. (1996). "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure". EMBO J. 15 (5): 1004–11. doi:10.1002/j.1460-2075.1996.tb00437.x. PMC 449995. PMID 8605869.
• Lesage F, Reyes R, Fink M, et al. (1997). "Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge". EMBO J. 15 (23): 6400–7. doi:10.1002/j.1460-2075.1996.tb01031.x. PMC 452465. PMID 8978667.
• Orias M, Velázquez H, Tung F, et al. (1997). "Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments". Am. J. Physiol. 273 (4 Pt 2): F663–6. doi:10.1152/ajprenal.1997.273.4.F663. PMID 9362344.
• Wang Z, Yue L, White M, et al. (1999). "Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle". Circulation. 98 (22): 2422–8. doi:10.1161/01.cir.98.22.2422. PMID 9832487.
• Medhurst AD, Rennie G, Chapman CG, et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. doi:10.1016/S0169-328X(00)00263-1. PMID 11165377.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nicolas MT, Barhanin J, Reyes R, Demêmes D (2004). "Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear". Hear. Res. 181 (1–2): 20–6. doi:10.1016/S0378-5955(03)00162-X. PMID 12855359. S2CID 23605830.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rajan S, Plant LD, Rabin ML, et al. (2005). "Sumoylation silences the plasma membrane leak K+ channel K2P1". Cell. 121 (1): 37–47. doi:10.1016/j.cell.2005.01.019. PMID 15820677. S2CID 6314155.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• KCNK1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.