Isobutane, also known as i-butane, 2-methylpropane or methylpropane, is a chemical compound with molecular formula HC(CH3)3. It is an isomer of butane. It is the simplest alkane with a tertiary carbon. Isobutane is used as a precursor molecule in the petrochemical industry, for example in the synthesis of isooctane.[6]

Chemical structure of isobutane with all atoms explicitly shown
Skeletal formula of isobutane
Ball and stick model of isobutane
Spacefill model of isobutane
Preferred IUPAC name
Other names
3D model (JSmol)
ECHA InfoCard 100.000.780
EC Number
  • 200-857-2
E number E943b (glazing agents, ...)
RTECS number
  • TZ4300000
UN number 1969
Molar mass 58.124 g·mol−1
Appearance Colorless gas
Odor Odorless
  • 2.51 kg/m3 (at 15 °C, 100 kPa)
  • 563 kg/m3 (at 15 °C, boiling liquid)
Melting point −159.42 °C (−254.96 °F; 113.73 K)[4]
Boiling point −11.7 °C (10.9 °F; 261.4 K)[4]
48.9 mg⋅L−1 (at 25 °C (77 °F))[2]
Vapor pressure 3.1 atm (310 kPa) (at 21 °C (294 K; 70 °F))[3]
8.6 nmol⋅Pa−1⋅kg−1
Conjugate acid Isobutanium
−51.7·10−6 cm3/mol
96.65 J⋅K−1⋅mol−1
−134.8  −133.6 kJ⋅mol−1
−2.86959  −2.86841 MJ⋅mol−1
Safety data sheet See: data page
GHS pictograms GHS02: Flammable
GHS Signal word Danger
NFPA 704 (fire diamond)
Flammability code 4: Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Flash point below 23 °C (73 °F). E.g. propaneHealth code 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no codeNFPA 704 four-colored diamond
Flash point −83 °C (−117 °F; 190 K)
460 °C (860 °F; 733 K)
Explosive limits 1.4–8.3%
NIOSH (US health exposure limits):
PEL (Permissible)
REL (Recommended)
TWA 800 ppm (1900 mg/m3)[5]
IDLH (Immediate danger)
Related compounds
Related alkane
Supplementary data page
Refractive index (n),
Dielectric constantr), etc.
Phase behaviour
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is ☑Y☒N ?)
Infobox references


Isobutane is obtained by isomerization of butane.



Isobutane is the principal feedstock in alkylation units of refineries. Using isobutane, gasoline-grade "blendstocks" are generated with high branching for good combustion characteristics. Typical products from isobutane are 2,4-dimethylpentane and especially 2,2,4-trimethylpentane.[7]

Typical acid-catalyzed route to 2,4-dimethylpentane.


In the Chevron Phillips slurry process for making high-density polyethylene, isobutane is used as a diluent. As the slurried polyethylene is removed, isobutane is "flashed" off, and condensed, and recycled back into the loop reactor for this purpose.[8]

Precursor to tert-Butyl hydroperoxideEdit

Isobutane is oxidized to tert-Butyl hydroperoxide, which is subsequently reacted with propylene to yield propylene oxide. The tert-butanol that results as a by-product is typically used to make gasoline additives such as methyl tert-butyl ether (MTBE).

Miscellaneous usesEdit

Isobutane is also used as a propellant for aerosol cans.

Isobutane is used as part of blended fuels, especially common in fuel canisters used for camping.[9]


Isobutane is used as a refrigerant.[10] Their use in refrigerators started in 1993 when Greenpeace presented the Greenfreeze project with the German company Foron.[11] In this regard, blends of pure, dry "isobutane" (R-600a) (that is, isobutane mixtures) have negligible ozone depletion potential and very low global warming potential (having a value of 3.3 times the GWP of carbon dioxide) and can serve as a functional replacement for R-12, R-22 (both of these being commonly known by the trademark Freon), R-134a, and other chlorofluorocarbon or hydrofluorocarbon refrigerants in conventional stationary refrigeration and air conditioning systems.

As a refrigerant, isobutane poses an explosion risk in addition to the hazards associated with non-flammable CFC refrigerants. Substitution of this refrigerant for motor vehicle air conditioning systems not originally designed for isobutane is widely prohibited or discouraged.[12][13][14][15][16][17][18]

Vendors and advocates of hydrocarbon refrigerants argue against such bans on the grounds that there have been very few such incidents relative to the number of vehicle air conditioning systems filled with hydrocarbons.[19][20]


The traditional name isobutane was still retained in the 1993 IUPAC recommendations,[21] but is no longer recommended according to the 2013 recommendations.[1] Since the longest continuous chain in isobutane contains only three carbon atoms, the preferred IUPAC name is 2-methylpropane but the locant (2-) is typically omitted in general nomenclature as redundant; C2 is the only position on a propane chain where a methyl substituent can be located without altering the main chain and forming the constitutional isomer n-butane.


  1. ^ a b Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 652. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4. The names ‘isobutane’, ‘isopentane’ and ‘neopentane’ are no longer recommended.
  2. ^ "Solubility in Water". PubChem. National Center for Biotechnology Information. Retrieved 6 April 2017.
  3. ^ "CDC - NIOSH Pocket Guide to Chemical Hazards - Isobutane". CDC - NIOSH Pocket Guide to Chemical Hazards. CDC. Retrieved 28 December 2018.
  4. ^ a b Record in the GESTIS Substance Database of the Institute for Occupational Safety and Health
  5. ^ a b c NIOSH Pocket Guide to Chemical Hazards. "#0350". National Institute for Occupational Safety and Health (NIOSH).
  6. ^ "Patent Watch, July 31, 2006". Archived from the original on March 11, 2007. Retrieved August 8, 2006.
  7. ^ Bipin V. Vora, Joseph A. Kocal, Paul T. Barger, Robert J. Schmidt, James A. Johnson (2003). "Alkylation". Kirk‐Othmer Encyclopedia of Chemical Technology. doi:10.1002/0471238961.0112112508011313.a01.pub2.CS1 maint: uses authors parameter (link)
  8. ^ Kenneth S. Whiteley. "Polyethylene". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a21_487.pub2.
  9. ^ Rietveld, Will (2005-02-08). "Frequently Asked Questions About Lightweight Canister Stoves and Fuels". Backpacking Light. Retrieved 2014-07-26.
  10. ^ "European Commission on retrofit refrigerants for stationary applications" (PDF). Archived from the original (PDF) on 2009-08-05. Retrieved 2010-10-29.
  11. ^ Page - March 15, 2010 (2010-03-15). "GreenFreeze". Greenpeace. Retrieved 2013-01-02.
  12. ^ "U.S. EPA hydrocarbon-refrigerants FAQ". Retrieved 2010-10-29.
  13. ^ "Compendium of hydrocarbon-refrigerant policy statements, October 2006" (PDF). Archived from the original (PDF) on 2014-08-08. Retrieved 2014-08-01.
  14. ^ "MACS bulletin: hydrocarbon refrigerant usage in vehicles" (PDF). Archived from the original (PDF) on 2011-01-05. Retrieved 2010-10-29.
  15. ^ "Society of Automotive Engineers hydrocarbon refrigerant bulletin". 2005-04-27. Archived from the original on 2005-05-05. Retrieved 2010-10-29.
  16. ^ "Saskatchewan Labour bulletin on hydrocarbon refrigerants in vehicles". 2010-06-29. Archived from the original on 2009-07-01. Retrieved 2010-10-29.
  17. ^ VASA on refrigerant legality & advisability Archived January 13, 2009, at the Wayback Machine
  18. ^ "Queensland (Australia) government warning on hydrocarbon refrigerants" (PDF). Archived from the original (PDF) on 2008-12-17. Retrieved 2010-10-29.
  19. ^ "New South Wales (Australia) Parliamentary record, 16 October 1997". 1997-10-16. Archived from the original on 1 July 2009. Retrieved 2010-10-29.
  20. ^ "New South Wales (Australia) Parliamentary record, 29 June 2000". Archived from the original on 22 May 2005. Retrieved 2010-10-29.
  21. ^ Panico, R.; & Powell, W. H. (Eds.) (1994). A Guide to IUPAC Nomenclature of Organic Compounds 1993. Oxford: Blackwell Science. ISBN 0-632-03488-2.CS1 maint: multiple names: authors list (link) CS1 maint: extra text: authors list (link)

External linksEdit