Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.

ITGA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2
External IDsOMIM: 192974; MGI: 96600; HomoloGene: 1662; GeneCards: ITGA2; OMA:ITGA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002203

NM_008396

RefSeq (protein)

NP_002194

NP_032422

Location (UCSC)Chr 5: 52.99 – 53.09 MbChr 13: 114.97 – 115.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.[5]

Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells.[6]

The DX5 monoclonal antibody recognizes mouse CD49b.[7]

Interactions

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CD49b has been shown to interact with MMP1.[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164171Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015533Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".
  6. ^ Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A (2013-06-01). "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells". Nature Medicine. 19 (6): 739–746. doi:10.1038/nm.3179. ISSN 1546-170X. PMID 23624599. S2CID 21305032.
  7. ^ Arase H, Saito T, Phillips JH, Lanier LL (August 2001). "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)". Journal of Immunology. 167 (3): 1141–4. doi:10.4049/jimmunol.167.3.1141. PMID 11466327.
  8. ^ Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001). "Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction". J. Biol. Chem. 276 (31): 29375–81. doi:10.1074/jbc.M102217200. PMID 11359774.
  9. ^ Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368–74. doi:10.1074/jbc.M104179200. PMID 11359786.
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Further reading

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