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Idarucizumab, sold under the brand name Praxbind, is a monoclonal antibody designed for the reversal of anticoagulant effects of dabigatran.[1][2]

Monoclonal antibody
TypeFab fragment
SourceHumanized (from mouse)
Clinical data
Trade namesPraxbind
SynonymsBI 655075
License data
ATC code
CAS Number
  • none
Chemical and physical data
Molar mass47.8 kg/mol g·mol−1

This drug was developed by Boehringer Ingelheim Pharmaceuticals. A study sponsored by the manufacturer found that idarucizumab effectively reversed anticoagulation by dabigatran within minutes.[3] It was FDA approved in October 2015.[4] In the United States the wholesale cost is $3500 US.[5]

See alsoEdit


  1. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Idarucizumab, American Medical Association.
  2. ^ World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 109" (PDF). WHO Drug Information. 27 (2).
  3. ^ Pollack, Charles V.; Reilly, Paul A.; Eikelboom, John; Glund, Stephan; Verhamme, Peter; Bernstein, Richard A.; Dubiel, Robert; Huisman, Menno V.; Hylek, Elaine M. (2015-08-06). "Idarucizumab for Dabigatran Reversal". The New England Journal of Medicine. 373 (6): 511–520. doi:10.1056/NEJMoa1502000. ISSN 1533-4406. PMID 26095746.
  4. ^ "Press Announcements - FDA approves Praxbind, the first reversal agent for the anticoagulant Pradaxa". Retrieved 2015-10-17.
  5. ^ Elia, Joe. "Dabigatran-Reversal Agent Price Set". Retrieved 20 October 2015.