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Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.[5][6][7]

ITPK1
Protein ITPK1 PDB 2odt.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITPK1, ITRPK1, inositol-tetrakisphosphate 1-kinase
External IDsOMIM: 601838 MGI: 2446159 HomoloGene: 8588 GeneCards: ITPK1
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for ITPK1
Genomic location for ITPK1
Band14q32.12Start92,936,914 bp[1]
End93,116,320 bp[1]
RNA expression pattern
PBB GE ITPK1 210197 at fs.png

PBB GE ITPK1 210740 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014216
NM_001142593
NM_001142594
NM_001363707

NM_172584

RefSeq (protein)

NP_001136065
NP_001136066
NP_055031
NP_001350636

NP_766172

Location (UCSC)Chr 14: 92.94 – 93.12 MbChr 12: 102.57 – 102.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.[8][9]

ReferencesEdit

  1. ^ a b c ENSG00000274958 GRCh38: Ensembl release 89: ENSG00000100605, ENSG00000274958 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057963 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J Biol Chem. 271 (20): 11904–10. doi:10.1074/jbc.271.20.11904. PMID 8662638.
  6. ^ Yang X, Shears SB (Jan 2001). "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase". Biochem J. 351 (3): 551–5. doi:10.1042/0264-6021:3510551. PMC 1221393. PMID 11042108.
  7. ^ "Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase".
  8. ^ Saiardi A, Cockcroft S (2008). "Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels". Sci Signal. 1 (4): pe5. doi:10.1126/stke.14pe5. PMID 18272466.
  9. ^ Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G (September 2007). "Integration of inositol phosphate signaling pathways via human ITPK1". J. Biol. Chem. 282 (38): 28117–25. doi:10.1074/jbc.M703121200. PMC 2244811. PMID 17616525.

Further readingEdit