IRF2BP2

Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene.

IRF2BP2
Identifiers
Aliases	IRF2BP2, interferon regulatory factor 2 binding protein 2, CVID14
External IDs	OMIM: 615332; MGI: 2443921; HomoloGene: 34290; GeneCards: IRF2BP2; OMA:IRF2BP2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.3 Start 234,604,269 bp End 234,610,178 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E2 Start 127,315,035 bp End 127,320,725 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of lactiferous gland lactiferous duct trachea pancreatic epithelial cell mucosa of paranasal sinus superior surface of tongue pylorus trigeminal ganglion tail of epididymis caput epididymis Top expressed in aortic valve ascending aorta molar hand stroma of bone marrow left lung lobe left colon body of femur foot right lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm nucleus nucleoplasm Biological process transcription, DNA-templated regulation of transcription, DNA-templated immature B cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 359948 270110 Ensembl ENSG00000168264 ENSMUSG00000051495 UniProt Q7Z5L9 E9Q1P8 RefSeq (mRNA) NM_182972 NM_001077397 NM_001164598 RefSeq (protein) NP_001070865 NP_892017 NP_001158070 Location (UCSC) Chr 1: 234.6 – 234.61 Mb Chr 8: 127.32 – 127.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Further reading

• Childs KS, Goodbourn S (2003). "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2". Nucleic Acids Res. 31 (12): 3016–26. doi:10.1093/nar/gkg431. PMC 162335. PMID 12799427.
• Tinnikov AA, Yeung KT, Das S, Samuels HH (2009). "Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells". Cancer Res. 69 (4): 1375–82. doi:10.1158/0008-5472.CAN-08-2896. PMC 4264605. PMID 19190336.
• Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
• Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
• Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP (2011). "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity". Mol. Cell. Biol. 31 (14): 2889–901. doi:10.1128/MCB.00974-10. PMC 3133407. PMID 21576369.
• Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF (2011). "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2". PLOS ONE. 6 (8): e24100. Bibcode:2011PLoSO...624100T. doi:10.1371/journal.pone.0024100. PMC 3162591. PMID 21887377.
• Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012). "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma". PLOS ONE. 7 (11): e49705. Bibcode:2012PLoSO...749705N. doi:10.1371/journal.pone.0049705. PMC 3504151. PMID 23185413.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.