Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.[5]

INHA
Identifiers
AliasesINHA, inhibin alpha subunit, inhibin subunit alpha
External IDsOMIM: 147380; MGI: 96569; HomoloGene: 1652; GeneCards: INHA; OMA:INHA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002191

NM_010564
NM_001329843

RefSeq (protein)

NP_002182

NP_001316772
NP_034694

Location (UCSC)Chr 2: 219.57 – 219.58 MbChr 1: 75.48 – 75.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease.

However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123999Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032968Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.
  6. ^ "Entrez Gene: INHA inhibin, alpha".

Further reading

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