IL13RA2

IL13RA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LB6
Identifiers
Aliases	IL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
External IDs	OMIM: 300130; MGI: 1277954; HomoloGene: 534; GeneCards: IL13RA2; OMA:IL13RA2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	115,019,977 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	146,212,188 bp
RNA expression pattern
	Top expressed in
	sperm; ; Descending thoracic aorta; ; ascending aorta; ; right testis; ; left testis; ; gonad; ; glomerulus; ; metanephric glomerulus; ; testicle; ; anterior pituitary;
	Top expressed in
	cumulus cell; ; pineal gland; ; mesenteric lymph nodes; ; uterus; ; lip; ; gastrula; ; ascending aorta; ; aortic valve; ; dentate gyrus of hippocampal formation granule cell; ; skin of external ear;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; signal transducer activity; protein binding; cytokine binding;
Cellular component	integral component of membrane; membrane; extracellular region; extracellular space; external side of plasma membrane; receptor complex;
Biological process	negative regulation of mast cell degranulation; negative regulation of immunoglobulin production; immunoglobulin mediated immune response; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3598
	16165
	ENSG00000123496
	ENSMUSG00000031289
	Q14627
	O88786
	NM_000640
	NM_008356; NM_001306059
	NP_000631
	NP_001292988; NP_032382
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.^[5]

Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.^[5]

Clinical Significance

IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas. ^[6]^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123496 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031289 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2".
^ Fujisawa T, Joshi B, Nakajima A, Puri RK (November 2009). "A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis". Cancer Research. 69 (22): 8678–85. doi:10.1158/0008-5472.CAN-09-2100. PMID 19887609.
^ Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK (September 2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988. S2CID 70773746.
^ Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T (February 2019). "Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma". Scientific Reports. 9 (1): 1281. Bibcode:2019NatSR...9.1281O. doi:10.1038/s41598-019-39018-3. PMC 6362032. PMID 30718742.
^ Joshi BH, Plautz GE, Puri RK (March 2000). "Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas". Cancer Research. 60 (5): 1168–72. PMID 10728667.

Andrews AL, Nasir T, Bucchieri F, Holloway JW, Holgate ST, Davies DE (October 2006). "IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts". The Journal of Allergy and Clinical Immunology. 118 (4): 858–65. doi:10.1016/j.jaci.2006.06.041. PMID 17030238.
Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P (July 1996). "Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain". The Journal of Biological Chemistry. 271 (28): 16921–6. doi:10.1074/jbc.271.28.16921. PMID 8663118.
Zhang JG, Hilton DJ, Willson TA, McFarlane C, Roberts BA, Moritz RL, Simpson RJ, Alexander WS, Metcalf D, Nicola NA (April 1997). "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains". The Journal of Biological Chemistry. 272 (14): 9474–80. doi:10.1074/jbc.272.14.9474. PMID 9083087.
Gauchat JF, Schlagenhauf E, Feng NP, Moser R, Yamage M, Jeannin P, Alouani S, Elson G, Notarangelo LD, Wells T, Eugster HP, Bonnefoy JY (April 1997). "A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor". European Journal of Immunology. 27 (4): 971–8. doi:10.1002/eji.1830270425. PMID 9130652. S2CID 23762963.
Guo J, Apiou F, Mellerin MP, Lebeau B, Jacques Y, Minvielle S (May 1997). "Chromosome mapping and expression of the human interleukin-13 receptor". Genomics. 42 (1): 141–5. doi:10.1006/geno.1997.4628. PMID 9177784.
Donaldson DD, Whitters MJ, Fitz LJ, Neben TY, Finnerty H, Henderson SL, O'Hara RM, Beier DR, Turner KJ, Wood CR, Collins M (September 1998). "The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1". Journal of Immunology. 161 (5): 2317–24. doi:10.4049/jimmunol.161.5.2317. PMID 9725226. S2CID 255357984.
Osawa M, Miyoshi S, Copeland NG, Gilbert DJ, Jenkins NA, Hiroyama T, Motohashi T, Nakamura Y, Iwama A, Nakauchi H (September 2000). "Characterization of the mouse interleukin-13 receptor alpha1 gene". Immunogenetics. 51 (11): 974–81. doi:10.1007/s002510000225. PMID 11003391. S2CID 9030454.
Kawakami K, Takeshita F, Puri RK (July 2001). "Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain". The Journal of Biological Chemistry. 276 (27): 25114–20. doi:10.1074/jbc.M100936200. PMID 11352909.
Daines MO, Hershey GK (March 2002). "A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma". The Journal of Biological Chemistry. 277 (12): 10387–93. doi:10.1074/jbc.M108109200. PMID 11786536.
Okano F, Storkus WJ, Chambers WH, Pollack IF, Okada H (September 2002). "Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain". Clinical Cancer Research. 8 (9): 2851–5. PMID 12231526.
Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, Jiménez-Zamudio L, García-Latorre E, León-Dorantes G, Blancas-González F, Paredes-Cabrera G, Cancino-Díaz ME (November 2002). "Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein". The Journal of Investigative Dermatology. 119 (5): 1114–20. doi:10.1046/j.1523-1747.2002.19509.x. PMID 12445201.
David M, Bertoglio J, Pierre J (November 2002). "TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression". Annals of the New York Academy of Sciences. 973 (1): 207–9. Bibcode:2002NYASA.973..207D. doi:10.1111/j.1749-6632.2002.tb04633.x. PMID 12485861. S2CID 86154739.
Wu AH, Low WC (July 2003). "Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter". Neuro-Oncology. 5 (3): 179–87. doi:10.1215/s1152851702000510. PMC 1920687. PMID 12816724.
Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K (July 2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". The Journal of Biological Chemistry. 280 (26): 24915–22. doi:10.1074/jbc.M502571200. PMID 15870068.
Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A (January 2006). "IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis". Nature Medicine. 12 (1): 99–106. doi:10.1038/nm1332. PMID 16327802. S2CID 38397076.
Daines MO, Tabata Y, Walker BA, Chen W, Warrier MR, Basu S, Hershey GK (June 2006). "Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling". Journal of Immunology. 176 (12): 7495–501. doi:10.4049/jimmunol.176.12.7495. PMID 16751396.
Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK (September 2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988. S2CID 70773746.
Granel B, Allanore Y, Chevillard C, Arnaud V, Marquet S, Weiller PJ, Durand JM, Harlé JR, Grange C, Frances Y, Berbis P, Gaudart J, de Micco P, Kahan A, Dessein A (October 2006). "IL13RA2 gene polymorphisms are associated with systemic sclerosis". The Journal of Rheumatology. 33 (10): 2015–9. PMID 16981293.

External links

IL13RA2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q14627 (Interleukin-13 receptor subunit alpha-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123496 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031289 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2".

[6] Fujisawa T, Joshi B, Nakajima A, Puri RK (November 2009). "A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis". Cancer Research. 69 (22): 8678–85. doi:10.1158/0008-5472.CAN-09-2100. PMID 19887609.

[7] Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK (September 2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988. S2CID 70773746.

[8] Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T (February 2019). "Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma". Scientific Reports. 9 (1): 1281. Bibcode:2019NatSR...9.1281O. doi:10.1038/s41598-019-39018-3. PMC 6362032. PMID 30718742.

[9] Joshi BH, Plautz GE, Puri RK (March 2000). "Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas". Cancer Research. 60 (5): 1168–72. PMID 10728667.

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IL13RA2

Contents

Function

Clinical Significance

See also

References

Further reading

External links