Serine/threonine-protein kinase, Intestinal cell kinase or ICK[5] is an enzyme that in humans is encoded by the ICK gene.[6][7]

CILK1
Identifiers
AliasesCILK1, ECO, LCK2, MRK, intestinal cell (MAK-like) kinase, intestinal cell kinase, EJM10, ICK, ciliogenesis associated kinase 1, hICK
External IDsOMIM: 612325; MGI: 1934157; HomoloGene: 69218; GeneCards: CILK1; OMA:CILK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001163780
NM_019987

RefSeq (protein)

NP_001157252
NP_064371

Location (UCSC)Chr 6: 53 – 53.06 MbChr 9: 78.02 – 78.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112144Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009828Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "ICK intestinal cell kinase [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-01-26.
  6. ^ Yang T, Jiang Y, Chen J (Jul 2002). "The identification and subcellular localization of human MRK". Biomol Eng. 19 (1): 1–4. doi:10.1016/S1389-0344(02)00002-3. PMID 12103360.
  7. ^ a b "Entrez Gene: ICK intestinal cell (MAK-like) kinase".

Further reading

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