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Hypovolemia also known as volume depletion is a state of decreased blood volume or diminished body fluid; more specifically, decrease in volume of blood plasma. It is thus the intravascular component of volume contraction (or loss of blood volume due to things such as bleeding or dehydration), but, as it also is the most essential one, hypovolemia and volume contraction are sometimes used synonymously.
|Other names||Oligemia, hypovolaemia, oligaemia, hypovolæmia, volume depletion|
|Symptoms||headache, fatigue, nausea, profuse sweating, dizziness|
Signs and symptomsEdit
Symptoms may not be present until 10–20% of total whole-blood volume is lost. Headache, fatigue, nausea, profuse sweating, and dizziness may occur as the condition develops.
Common causes of hypovolemia are:
Hypovolemia can be recognized by tachycardia, diminished blood pressure, and the absence of perfusion as assessed by skin signs (skin turning pale) and/or capillary refill on forehead, lips and nail beds. The patient may feel dizzy, faint, nauseated, or very thirsty. These signs are also characteristic of most types of shock.
Note that in children compensation can result in an artificially high blood pressure despite hypovolemia. Children typically compensate (maintain blood pressure despite loss of blood volume) for a longer period than adults (until their blood is depleted by more than half), but deteriorate rapidly and severely once they do begin to decompensate. Consequently, any possibility of internal bleeding in children should be treated aggressively.
Signs of external bleeding should be assessed, noting that individuals can bleed internally without external blood loss or otherwise apparent signs.
There should be considered possible mechanisms of injury that may have caused internal bleeding, such as ruptured or bruised internal organs. If trained to do so and if the situation permits, there should be conducted a secondary survey and checked the chest and abdomen for pain, deformity, guarding, discoloration or swelling. Bleeding into the abdominal cavity can cause the classical bruising patterns of Grey Turner's sign (bruising along the sides) or Cullen's sign (around the navel).
The 4 stages are sometimes known as the "Tennis" staging of hypovolemic shock, as the stages of blood loss (under 15% of volume, 15–30% of volume, 30–40% of volume and above 40% of volume) mimic the scores in a game of tennis: 15, 15–30, 30–40 and 40. It is basically the same as used in classifying bleeding by blood loss.
The signs and symptoms of the major stages of hypovolemic shock include:
|Stage 1||Stage 2||Stage 3||Stage 4|
|Blood loss||Up to 15% (750 mL)||15–30% (750–1500 mL)||30–40% (1500–2000 mL)||Over 40% (over 2000 mL)|
|Blood pressure||Normal (Maintained
|Increased diastolic BP||Systolic BP < 100||Systolic BP < 70|
|Heart rate||Normal||Slight tachycardia (> 100 bpm)||Tachycardia (> 120 bpm)||Extreme tachycardia (> 140 bpm) with weak pulse|
|Respiratory rate||Normal||Increased (> 20)||Tachypneic (> 30)||Extreme tachypnea|
|Mental status||Normal||Slight anxiety, restless||Altered, confused||Decreased LOC, lethargy, coma|
|Skin||Pallor||Pale, cool, clammy||Increased diaphoresis||Extreme diaphoresis; mottling possible|
|Urine output||Normal||20–30 mL/h||20 mL/h||Negligible|
In a hospital, physicians respond to a case of hypovolemic shock by conducting these investigations:
The most important step in treatment of hypovolemic shock is to identify and control the source of bleeding.
Medical personnel should immediately supply emergency oxygen to increase efficiency of the patient's remaining blood supply. This intervention can be life-saving.
The use of intravenous fluids (IVs) may help compensate for lost fluid volume, but IV fluids cannot carry oxygen the way blood does—however, researchers are developing blood substitutes that can. Infusing colloid or crystalloid IV fluids also dilutes clotting factors in the blood, increasing the risk of bleeding. Current best practice allow permissive hypotension in patients suffering from hypovolemic shock, both avoid overly diluting clotting factors and avoid artificially raising blood pressure to a point where it "blows off" clots that have formed.
Fluid replacement is beneficial in hypovolemia of stage 2, and is necessary in stage 3 and 4. See also the discussion of shock and the importance of treating reversible shock while it can still be countered.
The following interventions are carried out:
- IV access
- Oxygen as required
- Fresh frozen plasma or blood transfusion
- Surgical repair at sites of bleeding
Vasopressors (like (dopamine and noradrenaline) should generally be avoided, as they may result in further tissue ischemia and don't correct the primary problem. Fluids are the preferred choice of therapy.
In cases where loss of blood volume is clearly attributable to bleeding (as opposed to, e.g., dehydration), most medical practitioners prefer the term exsanguination for its greater specificity and descriptiveness, with the effect that the latter term is now more common in the relevant context.
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The term hypovolemia refers collectively to two distinct disorders: (1) volume depletion, which describes the loss of sodium from the extracellular space (i.e., intravascular and interstitial fluid) that occurs during gastrointestinal hemorrhage, vomiting, diarrhea, and diuresis; and (2) dehydration, which refers to the loss of intracellular water (and total body water) that ultimately causes cellular desiccation and elevates the plasma sodium concentration and osmolality.
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